Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival

Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival

Abstract. Background:. T cell dysfunction, which includes exhaustion, anergy, and senescence, is a distinct T cell differentiation state that occurs after antigen exposure. Although T cell dysfunction has been a cornerstone of cancer immunotherapy, its potential in transplant research, while not ye...

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Bibliographic Details
Main Authors: Wenjia Yuan, Hedong Zhang, Longkai Peng, Chao Chen, Chen Feng, Zhouqi Tang, Pengcheng Cui, Yaguang Li, Tengfang Li, Xia Qiu, Yan Cui, Yinqi Zeng, Jiadi Luo, Xubiao Xie, Yong Guo, Xin Jiang, Helong Dai, Sihan Zhou, Xiuyuan Hao
Format: Article
Language:English
Published: Wolters Kluwer 2025-05-01
Series:Chinese Medical Journal
Online Access:http://journals.lww.com/10.1097/CM9.0000000000003198
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