Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination

Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination

Abstract Background As COVID-19 becomes endemic and vaccines are annually adapted, exposure intervals and immune imprinting become critical considerations for vaccination strategy. Imprinting by the ancestral spike protein affected bivalent Wuhan-Hu-1/BA.4-5 vaccine responses. We assess the persiste...

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Bibliographic Details
Main Authors: Xammy Huu Wrynla, Timothy A. Bates, Mila Trank-Greene, Mastura Wahedi, Audrey Hinchliff, Marcel E. Curlin, Fikadu G. Tafesse
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00898-4
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