Evaluation of the Prognostic Value of Obesity, Vitamin D Concentrations, and Systemic Inflammatory Response Indexes (SIRI, SII, PIV) in Patients With Breast Cancer Scheduled for Neoadjuvant Treatment
Introduction: The purpose of this study was to determine the prognostic utility of vitamin D concentrations and BMI (body mass index) values and the systemic immune-inflammation index (SII), the systemic inflammation response index (SIRI) and the pan-immune-inflammation value (PIV) to predict the ac...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-08-01
|
| Series: | Breast Cancer: Basic and Clinical Research |
| Online Access: | https://doi.org/10.1177/11782234251369463 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849224173185925120 |
|---|---|
| author | Beata Kotowicz Malgorzata Fuksiewicz Magdalena Jodkiewicz Agata Makowka Agnieszka Jagiełło-Gruszfeld |
| author_facet | Beata Kotowicz Malgorzata Fuksiewicz Magdalena Jodkiewicz Agata Makowka Agnieszka Jagiełło-Gruszfeld |
| author_sort | Beata Kotowicz |
| collection | DOAJ |
| description | Introduction: The purpose of this study was to determine the prognostic utility of vitamin D concentrations and BMI (body mass index) values and the systemic immune-inflammation index (SII), the systemic inflammation response index (SIRI) and the pan-immune-inflammation value (PIV) to predict the achievement of a complete response to neoadjuvant treatment (NAT) in patients with breast cancer. The correlations between systemic inflammatory response indices and vitamin D concentrations and BMI values were also analysed. Material and Methods: The study included 96 patients with breast cancer, prior to the start of NAT, of which 51 patients were diagnosed with triple-negative breast cancer (TNBC) and 45 patients with human epidermal growth factor receptor type 2 (HER2)-positive type. Results: The SIRI and PIV indices were shown to be significantly higher in patients with TNBC ( P = .001; P = .001) than in patients with HER2. There were no statistical differences in SII, SIRI, PIV, BMI, and vitamin D, according to the response to NAT treatment (pCR vs non-pCR). In the HER2+ group without pCR after NAT, there was a positive correlation of the SII coefficient with BMI values ( R = .41; P = .045). Furthermore, in the entire HER2+ group (irrespective of the NAT response), SII values were negatively correlated with vitamin D levels ( R = −0.39; P = .008). Conclusions: In patients with breast cancer, high SIRI and PIV values may indicate the biological subtype of TNBC. In the HER2+ group, higher SII values were associated with low vitamin D concentrations and elevated BMI. |
| format | Article |
| id | doaj-art-d2d10343d9884796a5dd4d6854014baf |
| institution | Kabale University |
| issn | 1178-2234 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Breast Cancer: Basic and Clinical Research |
| spelling | doaj-art-d2d10343d9884796a5dd4d6854014baf2025-08-25T15:03:36ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342025-08-011910.1177/11782234251369463Evaluation of the Prognostic Value of Obesity, Vitamin D Concentrations, and Systemic Inflammatory Response Indexes (SIRI, SII, PIV) in Patients With Breast Cancer Scheduled for Neoadjuvant TreatmentBeata Kotowicz0Malgorzata Fuksiewicz1Magdalena Jodkiewicz2Agata Makowka3Agnieszka Jagiełło-Gruszfeld4Cancer Biomarkers and Cytokines Laboratory Unit, Maria Sklodowska-Curie National Research Institute of Oncology, Warszawa, PolandCancer Biomarkers and Cytokines Laboratory Unit, Maria Sklodowska-Curie National Research Institute of Oncology, Warszawa, PolandMedical Center of Dietetics and Health Education, National Institute of Public Health – National Institute of Hygiene, Warsaw, PolandCancer Biomarkers and Cytokines Laboratory Unit, Maria Sklodowska-Curie National Research Institute of Oncology, Warszawa, PolandOncological Department, Masovian Oncology Hospital, Warsaw, PolandIntroduction: The purpose of this study was to determine the prognostic utility of vitamin D concentrations and BMI (body mass index) values and the systemic immune-inflammation index (SII), the systemic inflammation response index (SIRI) and the pan-immune-inflammation value (PIV) to predict the achievement of a complete response to neoadjuvant treatment (NAT) in patients with breast cancer. The correlations between systemic inflammatory response indices and vitamin D concentrations and BMI values were also analysed. Material and Methods: The study included 96 patients with breast cancer, prior to the start of NAT, of which 51 patients were diagnosed with triple-negative breast cancer (TNBC) and 45 patients with human epidermal growth factor receptor type 2 (HER2)-positive type. Results: The SIRI and PIV indices were shown to be significantly higher in patients with TNBC ( P = .001; P = .001) than in patients with HER2. There were no statistical differences in SII, SIRI, PIV, BMI, and vitamin D, according to the response to NAT treatment (pCR vs non-pCR). In the HER2+ group without pCR after NAT, there was a positive correlation of the SII coefficient with BMI values ( R = .41; P = .045). Furthermore, in the entire HER2+ group (irrespective of the NAT response), SII values were negatively correlated with vitamin D levels ( R = −0.39; P = .008). Conclusions: In patients with breast cancer, high SIRI and PIV values may indicate the biological subtype of TNBC. In the HER2+ group, higher SII values were associated with low vitamin D concentrations and elevated BMI.https://doi.org/10.1177/11782234251369463 |
| spellingShingle | Beata Kotowicz Malgorzata Fuksiewicz Magdalena Jodkiewicz Agata Makowka Agnieszka Jagiełło-Gruszfeld Evaluation of the Prognostic Value of Obesity, Vitamin D Concentrations, and Systemic Inflammatory Response Indexes (SIRI, SII, PIV) in Patients With Breast Cancer Scheduled for Neoadjuvant Treatment Breast Cancer: Basic and Clinical Research |
| title | Evaluation of the Prognostic Value of Obesity, Vitamin D Concentrations, and Systemic Inflammatory Response Indexes (SIRI, SII, PIV) in Patients With Breast Cancer Scheduled for Neoadjuvant Treatment |
| title_full | Evaluation of the Prognostic Value of Obesity, Vitamin D Concentrations, and Systemic Inflammatory Response Indexes (SIRI, SII, PIV) in Patients With Breast Cancer Scheduled for Neoadjuvant Treatment |
| title_fullStr | Evaluation of the Prognostic Value of Obesity, Vitamin D Concentrations, and Systemic Inflammatory Response Indexes (SIRI, SII, PIV) in Patients With Breast Cancer Scheduled for Neoadjuvant Treatment |
| title_full_unstemmed | Evaluation of the Prognostic Value of Obesity, Vitamin D Concentrations, and Systemic Inflammatory Response Indexes (SIRI, SII, PIV) in Patients With Breast Cancer Scheduled for Neoadjuvant Treatment |
| title_short | Evaluation of the Prognostic Value of Obesity, Vitamin D Concentrations, and Systemic Inflammatory Response Indexes (SIRI, SII, PIV) in Patients With Breast Cancer Scheduled for Neoadjuvant Treatment |
| title_sort | evaluation of the prognostic value of obesity vitamin d concentrations and systemic inflammatory response indexes siri sii piv in patients with breast cancer scheduled for neoadjuvant treatment |
| url | https://doi.org/10.1177/11782234251369463 |
| work_keys_str_mv | AT beatakotowicz evaluationoftheprognosticvalueofobesityvitamindconcentrationsandsystemicinflammatoryresponseindexessirisiipivinpatientswithbreastcancerscheduledforneoadjuvanttreatment AT malgorzatafuksiewicz evaluationoftheprognosticvalueofobesityvitamindconcentrationsandsystemicinflammatoryresponseindexessirisiipivinpatientswithbreastcancerscheduledforneoadjuvanttreatment AT magdalenajodkiewicz evaluationoftheprognosticvalueofobesityvitamindconcentrationsandsystemicinflammatoryresponseindexessirisiipivinpatientswithbreastcancerscheduledforneoadjuvanttreatment AT agatamakowka evaluationoftheprognosticvalueofobesityvitamindconcentrationsandsystemicinflammatoryresponseindexessirisiipivinpatientswithbreastcancerscheduledforneoadjuvanttreatment AT agnieszkajagiełłogruszfeld evaluationoftheprognosticvalueofobesityvitamindconcentrationsandsystemicinflammatoryresponseindexessirisiipivinpatientswithbreastcancerscheduledforneoadjuvanttreatment |