Breaking the synergism of iron overload and miR-122 to rescue lipid accumulation and peroxidation in MASLD

Breaking the synergism of iron overload and miR-122 to rescue lipid accumulation and peroxidation in MASLD

MASLD is a multifactorial disease with specific subtypes being featured by hepatic iron overload and loss of miR-122, a liver-specific microRNA regulating hepatic lipid homeostasis. Previously we reported the mechanism of iron overload decreasing miR-122. Interestingly, we found that mice lacking mi...

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Bibliographic Details
Main Authors: Yuxiao Tang, Zelong Gao, Jianxin Yang, Chenqi Li, Weili Wang, Chenghua Wu, Mengpu Wu, Min Li, Huiwen Wu, Yan Sun, Hongwei Zhang, Yifeng Chai, Feng Xie, Jianxin Qian, Hui Shen, Dongyao Wang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Pharmacological Research
Subjects:
MASLD
MiR-122
Iron overload
Lipid peroxidation
Polyunsaturated fatty acids
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001537
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