EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE
Among drug-resistant epilepsies, epileptic syndromes, characterized by combination of several types of seizures, are considered to be the most difficult in terms of treatment. Lennox–Gastaut syndrome is one of them. It manifests with polymorphic seizures (tonic axial, myatonic, atypical absence seiz...
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| Language: | Russian |
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ABV-press
2017-02-01
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| Series: | Русский журнал детской неврологии |
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| Online Access: | https://rjdn.abvpress.ru/jour/article/view/185 |
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| author | I. O. Shchederkina K. A. Orlova I. E. Koltunov M. Yu. Dorofeeva |
| author_facet | I. O. Shchederkina K. A. Orlova I. E. Koltunov M. Yu. Dorofeeva |
| author_sort | I. O. Shchederkina |
| collection | DOAJ |
| description | Among drug-resistant epilepsies, epileptic syndromes, characterized by combination of several types of seizures, are considered to be the most difficult in terms of treatment. Lennox–Gastaut syndrome is one of them. It manifests with polymorphic seizures (tonic axial, myatonic, atypical absence seizures, status epilepticus of minor motor seizures, myoclonic, generalized convulsive, and focal seizures). This is a heterogeneous disease, represented by a complex of clinical and electroencephalographic manifestations with various etiology. Current review is devoted to a novel antiepileptic drug rufinamide, which has a new mechanism of action. The drug has been registered in Russia in 2015. The authors also describe their own experience of rufinamide usage in the treatment of drug-resistant focal epilepsy as a part of multicomponent therapy for polymorphic seizures. One patient achieved clinical remission for 16 months; the second one had more than 50 % decrease in seizures frequency with a remission of drop-attacks. |
| format | Article |
| id | doaj-art-d2ce1cf736aa477c8344a55ace4ba906 |
| institution | DOAJ |
| issn | 2073-8803 2412-9178 |
| language | Russian |
| publishDate | 2017-02-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Русский журнал детской неврологии |
| spelling | doaj-art-d2ce1cf736aa477c8344a55ace4ba9062025-08-20T02:56:07ZrusABV-pressРусский журнал детской неврологии2073-88032412-91782017-02-01114546010.17650/2073-8803-2016-11-4-54-60139EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICEI. O. Shchederkina0K. A. Orlova1I. E. Koltunov2M. Yu. Dorofeeva3Morozov Children’s City Clinical Hospital, Moscow Healthcare Department; N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaMorozov Children’s City Clinical Hospital, Moscow Healthcare Department; N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaMorozov Children’s City Clinical Hospital, Moscow Healthcare Department; Peoples’ Friendship University of RussiaAcad. Yu.E. Vel’tishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaAmong drug-resistant epilepsies, epileptic syndromes, characterized by combination of several types of seizures, are considered to be the most difficult in terms of treatment. Lennox–Gastaut syndrome is one of them. It manifests with polymorphic seizures (tonic axial, myatonic, atypical absence seizures, status epilepticus of minor motor seizures, myoclonic, generalized convulsive, and focal seizures). This is a heterogeneous disease, represented by a complex of clinical and electroencephalographic manifestations with various etiology. Current review is devoted to a novel antiepileptic drug rufinamide, which has a new mechanism of action. The drug has been registered in Russia in 2015. The authors also describe their own experience of rufinamide usage in the treatment of drug-resistant focal epilepsy as a part of multicomponent therapy for polymorphic seizures. One patient achieved clinical remission for 16 months; the second one had more than 50 % decrease in seizures frequency with a remission of drop-attacks.https://rjdn.abvpress.ru/jour/article/view/185drug-resistant epilepsypolymorphic seizureslennox–gastaut syndromerufinamideinovelon |
| spellingShingle | I. O. Shchederkina K. A. Orlova I. E. Koltunov M. Yu. Dorofeeva EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE Русский журнал детской неврологии drug-resistant epilepsy polymorphic seizures lennox–gastaut syndrome rufinamide inovelon |
| title | EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE |
| title_full | EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE |
| title_fullStr | EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE |
| title_full_unstemmed | EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE |
| title_short | EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE |
| title_sort | efficacy of rufinamide in the treatment of drug resistant focal epilepsies in paediatric practice |
| topic | drug-resistant epilepsy polymorphic seizures lennox–gastaut syndrome rufinamide inovelon |
| url | https://rjdn.abvpress.ru/jour/article/view/185 |
| work_keys_str_mv | AT ioshchederkina efficacyofrufinamideinthetreatmentofdrugresistantfocalepilepsiesinpaediatricpractice AT kaorlova efficacyofrufinamideinthetreatmentofdrugresistantfocalepilepsiesinpaediatricpractice AT iekoltunov efficacyofrufinamideinthetreatmentofdrugresistantfocalepilepsiesinpaediatricpractice AT myudorofeeva efficacyofrufinamideinthetreatmentofdrugresistantfocalepilepsiesinpaediatricpractice |