Acute myocardial infarction following inhaled treprostinil initiation
An 81-year-old man with a history of interstitial lung disease attributed to idiopathic pulmonary fibrosis, severe aortic stenosis, and stable coronary artery disease was started on inhaled treprostinil for pulmonary hypertension associated with interstitial lung disease to optimize hemodynamics pri...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Respiratory Medicine Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007125000206 |
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| author | Bilal Alqam Sarah Medrek |
| author_facet | Bilal Alqam Sarah Medrek |
| author_sort | Bilal Alqam |
| collection | DOAJ |
| description | An 81-year-old man with a history of interstitial lung disease attributed to idiopathic pulmonary fibrosis, severe aortic stenosis, and stable coronary artery disease was started on inhaled treprostinil for pulmonary hypertension associated with interstitial lung disease to optimize hemodynamics prior to the valve replacement procedure. However, two days after starting this treatment, the patient presented with an inferior-posterior ST elevation myocardial infarction. Urgent coronary angiography revealed a 95 % proximal right coronary artery stenosis, successfully treated with percutaneous coronary intervention and drug-eluting stent placement. This case raises a question of whether there could be a potential association between inhaled treprostinil initiation and acute myocardial infarction in patients with underlying coronary artery disease. With the documented stability of the patient's coronary artery disease prior to medication initiation, it is plausible to question whether treprostinil may have played a role in plaque destabilization. |
| format | Article |
| id | doaj-art-d2cc4bd6a9894a2f824bbd0909ce0da1 |
| institution | Kabale University |
| issn | 2213-0071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-d2cc4bd6a9894a2f824bbd0909ce0da12025-08-20T03:44:21ZengElsevierRespiratory Medicine Case Reports2213-00712025-01-015410218410.1016/j.rmcr.2025.102184Acute myocardial infarction following inhaled treprostinil initiationBilal Alqam0Sarah Medrek1Division of Cardiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USADivision of Pulmonary, Critical Care, Sleep Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Division of Pulmonary, Critical Care, Sleep Medicine, New Mexico Veterans Affairs Health Care System, Albuquerque, NM, USA; Corresponding author. Section Chief of Pulmonary, Critical Care, Sleep Medicine at NMVAHCS University of New Mexico School of Medicine 1501 San Pedro Dr SE Building 41, Room 5B-121 Albuquerque, NM 87108, USA.An 81-year-old man with a history of interstitial lung disease attributed to idiopathic pulmonary fibrosis, severe aortic stenosis, and stable coronary artery disease was started on inhaled treprostinil for pulmonary hypertension associated with interstitial lung disease to optimize hemodynamics prior to the valve replacement procedure. However, two days after starting this treatment, the patient presented with an inferior-posterior ST elevation myocardial infarction. Urgent coronary angiography revealed a 95 % proximal right coronary artery stenosis, successfully treated with percutaneous coronary intervention and drug-eluting stent placement. This case raises a question of whether there could be a potential association between inhaled treprostinil initiation and acute myocardial infarction in patients with underlying coronary artery disease. With the documented stability of the patient's coronary artery disease prior to medication initiation, it is plausible to question whether treprostinil may have played a role in plaque destabilization.http://www.sciencedirect.com/science/article/pii/S2213007125000206Pulmonary hypertensionAcute myocardial infarctionProstacyclin analogue |
| spellingShingle | Bilal Alqam Sarah Medrek Acute myocardial infarction following inhaled treprostinil initiation Respiratory Medicine Case Reports Pulmonary hypertension Acute myocardial infarction Prostacyclin analogue |
| title | Acute myocardial infarction following inhaled treprostinil initiation |
| title_full | Acute myocardial infarction following inhaled treprostinil initiation |
| title_fullStr | Acute myocardial infarction following inhaled treprostinil initiation |
| title_full_unstemmed | Acute myocardial infarction following inhaled treprostinil initiation |
| title_short | Acute myocardial infarction following inhaled treprostinil initiation |
| title_sort | acute myocardial infarction following inhaled treprostinil initiation |
| topic | Pulmonary hypertension Acute myocardial infarction Prostacyclin analogue |
| url | http://www.sciencedirect.com/science/article/pii/S2213007125000206 |
| work_keys_str_mv | AT bilalalqam acutemyocardialinfarctionfollowinginhaledtreprostinilinitiation AT sarahmedrek acutemyocardialinfarctionfollowinginhaledtreprostinilinitiation |