Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries
Alcohol is readily distributed throughout the body in the blood stream and crosses biological membranes, which affect virtually all biological processes inside the cell. Excessive alcohol consumption induces numerous pathological stress responses, part of which is endoplasmic reticulum (ER) stress r...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/216450 |
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| author | Cheng Ji |
| author_facet | Cheng Ji |
| author_sort | Cheng Ji |
| collection | DOAJ |
| description | Alcohol is readily distributed throughout the body in the blood stream and crosses biological membranes, which affect virtually all biological processes inside the cell. Excessive alcohol consumption induces numerous pathological stress responses, part of which is endoplasmic reticulum (ER) stress response. ER stress, a condition under which unfolded/misfolded protein accumulates in the ER, contributes to alcoholic disorders of major organs such as liver, pancreas, heart, and brain. Potential mechanisms that trigger the alcoholic ER stress response are directly or indirectly related to alcohol metabolism, which includes toxic acetaldehyde and homocysteine, oxidative stress, perturbations of calcium or iron homeostasis, alterations of S-adenosylmethionine to S-adenosylhomocysteine ratio, and abnormal epigenetic modifications. Interruption of the ER stress triggers is anticipated to have therapeutic benefits for alcoholic disorders. |
| format | Article |
| id | doaj-art-d2cb9a99b3894067b1fb5e7b493e30d6 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-d2cb9a99b3894067b1fb5e7b493e30d62025-02-03T01:27:41ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/216450216450Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ InjuriesCheng Ji0Southern California Research Center for ALPD and Cirrhosis, USC Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USAAlcohol is readily distributed throughout the body in the blood stream and crosses biological membranes, which affect virtually all biological processes inside the cell. Excessive alcohol consumption induces numerous pathological stress responses, part of which is endoplasmic reticulum (ER) stress response. ER stress, a condition under which unfolded/misfolded protein accumulates in the ER, contributes to alcoholic disorders of major organs such as liver, pancreas, heart, and brain. Potential mechanisms that trigger the alcoholic ER stress response are directly or indirectly related to alcohol metabolism, which includes toxic acetaldehyde and homocysteine, oxidative stress, perturbations of calcium or iron homeostasis, alterations of S-adenosylmethionine to S-adenosylhomocysteine ratio, and abnormal epigenetic modifications. Interruption of the ER stress triggers is anticipated to have therapeutic benefits for alcoholic disorders.http://dx.doi.org/10.1155/2012/216450 |
| spellingShingle | Cheng Ji Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries Biochemistry Research International |
| title | Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries |
| title_full | Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries |
| title_fullStr | Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries |
| title_full_unstemmed | Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries |
| title_short | Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries |
| title_sort | mechanisms of alcohol induced endoplasmic reticulum stress and organ injuries |
| url | http://dx.doi.org/10.1155/2012/216450 |
| work_keys_str_mv | AT chengji mechanismsofalcoholinducedendoplasmicreticulumstressandorganinjuries |