The Effect of Interferon-Inducible T Cell Alpha Chemoattractant (I-TAC) on Transplanted Mice with Breast Cancer
Background: Interferon-inducible T-cell alpha chemoattractant (I-TAC, CXCL11) is a novel chemokine that used as immunotherapy. CXCL11 develops an effective anti-tumor immune response that relies on the coordinated interactions between immunocompetent cells, suppress angiogenesis and leading to...
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| Format: | Article |
| Language: | English |
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Al-Nahrain University/College of medicine
2023-06-01
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| Series: | The Iraqi Journal of Medical Sciences |
| Online Access: | https://www.iraqijms.net/index.php?do=view&type=article&id=859 |
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| author | Hind Mohammed Arwa Al-Shuwaikh Ahmed Al-Shammari |
| author_facet | Hind Mohammed Arwa Al-Shuwaikh Ahmed Al-Shammari |
| author_sort | Hind Mohammed |
| collection | DOAJ |
| description |
Background: Interferon-inducible T-cell alpha chemoattractant (I-TAC, CXCL11) is a novel chemokine that used as immunotherapy. CXCL11 develops an effective anti-tumor immune response that relies on the coordinated interactions between immunocompetent cells, suppress angiogenesis and leading to an anti-tumor effect.
Objective: To investigate the anti-tumor effect of CXCL11 on breast cancer transplanted in an animal’s model.
Methods: CXCL11 adoptive immunotherapy inducible, was intratumorally injected in mice breast cancer model one dose weekly for three weeks, each dose concentration 20 ng/100μl. Weight of mouse and size of tumor were recorded every 48 hr until 25 days. Parameters examined on mice transplanted with murine mammary adenocarcinoma (AMN3) cells (to study the therapeutic of CXCL11 in vivo) were included growth inhibition (GI%), relative tumor volume (RTV), relative mice weight (RMW) and survival time in mice.
Results: In-vivo CXCL11 treatment showed to induce GI% from day 3 and continued to day 25 with significant increase in mice weight in comparison to non-treated control group during 25 days (P<0.0001). Also, the CXCL11 treatment exhibited a significant reduction in RTV and improving survival time in mice.
Conclusion: CXCL11 showed an anti-cancer effect on breast cancer AMN3 implanted in mice compared to control. CXCL11 may have immunotherapeutic effect on breast cancer by triggering the activation of immunity against cancer.
Keywords: Breast cancer, CXCL11, immunotherapy, AMN3
Citation: Mohammed HA, Al-Shuwaikh AM, Al-Shammari AM. The effect of interferon-inducible T cell alpha chemoattractant (I-TAC) on transplanted mice with breast cancer. Iraqi JMS. 2023; 21(1): 81-87. doi: 10.22578/IJMS.21.1.8 |
| format | Article |
| id | doaj-art-d2c951e6ce9347a8803bf69b614e194f |
| institution | Kabale University |
| issn | 1681-6579 2224-4719 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Al-Nahrain University/College of medicine |
| record_format | Article |
| series | The Iraqi Journal of Medical Sciences |
| spelling | doaj-art-d2c951e6ce9347a8803bf69b614e194f2024-12-13T20:02:34ZengAl-Nahrain University/College of medicineThe Iraqi Journal of Medical Sciences1681-65792224-47192023-06-01211818710.22578/IJMS.21.1.8The Effect of Interferon-Inducible T Cell Alpha Chemoattractant (I-TAC) on Transplanted Mice with Breast CancerHind MohammedArwa Al-ShuwaikhAhmed Al-Shammari Background: Interferon-inducible T-cell alpha chemoattractant (I-TAC, CXCL11) is a novel chemokine that used as immunotherapy. CXCL11 develops an effective anti-tumor immune response that relies on the coordinated interactions between immunocompetent cells, suppress angiogenesis and leading to an anti-tumor effect. Objective: To investigate the anti-tumor effect of CXCL11 on breast cancer transplanted in an animal’s model. Methods: CXCL11 adoptive immunotherapy inducible, was intratumorally injected in mice breast cancer model one dose weekly for three weeks, each dose concentration 20 ng/100μl. Weight of mouse and size of tumor were recorded every 48 hr until 25 days. Parameters examined on mice transplanted with murine mammary adenocarcinoma (AMN3) cells (to study the therapeutic of CXCL11 in vivo) were included growth inhibition (GI%), relative tumor volume (RTV), relative mice weight (RMW) and survival time in mice. Results: In-vivo CXCL11 treatment showed to induce GI% from day 3 and continued to day 25 with significant increase in mice weight in comparison to non-treated control group during 25 days (P<0.0001). Also, the CXCL11 treatment exhibited a significant reduction in RTV and improving survival time in mice. Conclusion: CXCL11 showed an anti-cancer effect on breast cancer AMN3 implanted in mice compared to control. CXCL11 may have immunotherapeutic effect on breast cancer by triggering the activation of immunity against cancer. Keywords: Breast cancer, CXCL11, immunotherapy, AMN3 Citation: Mohammed HA, Al-Shuwaikh AM, Al-Shammari AM. The effect of interferon-inducible T cell alpha chemoattractant (I-TAC) on transplanted mice with breast cancer. Iraqi JMS. 2023; 21(1): 81-87. doi: 10.22578/IJMS.21.1.8https://www.iraqijms.net/index.php?do=view&type=article&id=859 |
| spellingShingle | Hind Mohammed Arwa Al-Shuwaikh Ahmed Al-Shammari The Effect of Interferon-Inducible T Cell Alpha Chemoattractant (I-TAC) on Transplanted Mice with Breast Cancer The Iraqi Journal of Medical Sciences |
| title | The Effect of Interferon-Inducible T Cell Alpha Chemoattractant (I-TAC) on Transplanted Mice with Breast Cancer |
| title_full | The Effect of Interferon-Inducible T Cell Alpha Chemoattractant (I-TAC) on Transplanted Mice with Breast Cancer |
| title_fullStr | The Effect of Interferon-Inducible T Cell Alpha Chemoattractant (I-TAC) on Transplanted Mice with Breast Cancer |
| title_full_unstemmed | The Effect of Interferon-Inducible T Cell Alpha Chemoattractant (I-TAC) on Transplanted Mice with Breast Cancer |
| title_short | The Effect of Interferon-Inducible T Cell Alpha Chemoattractant (I-TAC) on Transplanted Mice with Breast Cancer |
| title_sort | effect of interferon inducible t cell alpha chemoattractant i tac on transplanted mice with breast cancer |
| url | https://www.iraqijms.net/index.php?do=view&type=article&id=859 |
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