Quantification of mast cells in different stages of periodontal disease
Background/Aim. Mast cells are mononuclear cells originating from bone marrow. They produce various biologically active substances, which allow them to actively participate in immune and inflammatory processes associated with periodontal disease. The study focused on distribution and densit...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2016-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600030M.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850228925659086848 |
|---|---|
| author | Marjanović Dragan Anđelković Zlatibor Brkić Zlata Videnović Goran Šehalić Meliha Matvjenko Vladimir Leštarević Snežana Đorđević Nadica |
| author_facet | Marjanović Dragan Anđelković Zlatibor Brkić Zlata Videnović Goran Šehalić Meliha Matvjenko Vladimir Leštarević Snežana Đorđević Nadica |
| author_sort | Marjanović Dragan |
| collection | DOAJ |
| description | Background/Aim. Mast cells are mononuclear cells originating from bone
marrow. They produce various biologically active substances, which allow them
to actively participate in immune and inflammatory processes associated with
periodontal disease. The study focused on distribution and density of mast
cells in healthy gingiva as well as in different stages of periodontal
disease. Methods. The material used for this purpose was gingival biopsies
taken from 96 patients classified into 4 groups: healthy gingiva, gingivitis,
initial and severe periodontal disease. Toluidine blue staining according to
Spicer was utilized for identifying mast cells. Results. Basing on our study,
the density of mast cells in the gingival tissue increases with the
progression of the infection, which means they are more numerous in
gingivitis compared to healthy gingiva, as well as in periodontal disease
compared to gingivitis. Conclusion. Increase in the number of mast cells in
the infected gingiva can be correlated with an increased influx of
inflammatory cells from blood circulation into the gingival stroma, as well
as with the collagen lysis, since these cells produce substances with
collagenolytic potential. Based on the distribution of mast cells, it could
be concluded that in the evolution of periodontal disease there are
significant dynamic alterations in migration and localization of these cells. |
| format | Article |
| id | doaj-art-d2c6fb5c06c4471692c293ddcd4f9776 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-d2c6fb5c06c4471692c293ddcd4f97762025-08-20T02:04:23ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202016-01-0173545846210.2298/VSP141222030M0042-84501600030MQuantification of mast cells in different stages of periodontal diseaseMarjanović Dragan0Anđelković Zlatibor1Brkić Zlata2Videnović Goran3Šehalić Meliha4Matvjenko Vladimir5Leštarević Snežana6Đorđević Nadica7Faculty of Medicine, Dental Clinic, Kosovska MitrovicaFaculty of Medicine, Institute for Histology and Embryology, Kosovska MitrovicaMilitary Medical Academy, Dental Clinic, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeFaculty of Medicine, Dental Clinic, Kosovska MitrovicaFaculty of Medicine, Dental Clinic, Kosovska MitrovicaFaculty of Medicine, Dental Clinic, Kosovska MitrovicaMilitary Medical Academy, Dental Clinic, BelgradeFaculty of Medicine, Dental Clinic, Kosovska MitrovicaBackground/Aim. Mast cells are mononuclear cells originating from bone marrow. They produce various biologically active substances, which allow them to actively participate in immune and inflammatory processes associated with periodontal disease. The study focused on distribution and density of mast cells in healthy gingiva as well as in different stages of periodontal disease. Methods. The material used for this purpose was gingival biopsies taken from 96 patients classified into 4 groups: healthy gingiva, gingivitis, initial and severe periodontal disease. Toluidine blue staining according to Spicer was utilized for identifying mast cells. Results. Basing on our study, the density of mast cells in the gingival tissue increases with the progression of the infection, which means they are more numerous in gingivitis compared to healthy gingiva, as well as in periodontal disease compared to gingivitis. Conclusion. Increase in the number of mast cells in the infected gingiva can be correlated with an increased influx of inflammatory cells from blood circulation into the gingival stroma, as well as with the collagen lysis, since these cells produce substances with collagenolytic potential. Based on the distribution of mast cells, it could be concluded that in the evolution of periodontal disease there are significant dynamic alterations in migration and localization of these cells.http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600030M.pdfperiodontal diseasesdisease progressionmast cells |
| spellingShingle | Marjanović Dragan Anđelković Zlatibor Brkić Zlata Videnović Goran Šehalić Meliha Matvjenko Vladimir Leštarević Snežana Đorđević Nadica Quantification of mast cells in different stages of periodontal disease Vojnosanitetski Pregled periodontal diseases disease progression mast cells |
| title | Quantification of mast cells in different stages of periodontal disease |
| title_full | Quantification of mast cells in different stages of periodontal disease |
| title_fullStr | Quantification of mast cells in different stages of periodontal disease |
| title_full_unstemmed | Quantification of mast cells in different stages of periodontal disease |
| title_short | Quantification of mast cells in different stages of periodontal disease |
| title_sort | quantification of mast cells in different stages of periodontal disease |
| topic | periodontal diseases disease progression mast cells |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600030M.pdf |
| work_keys_str_mv | AT marjanovicdragan quantificationofmastcellsindifferentstagesofperiodontaldisease AT anđelkoviczlatibor quantificationofmastcellsindifferentstagesofperiodontaldisease AT brkiczlata quantificationofmastcellsindifferentstagesofperiodontaldisease AT videnovicgoran quantificationofmastcellsindifferentstagesofperiodontaldisease AT sehalicmeliha quantificationofmastcellsindifferentstagesofperiodontaldisease AT matvjenkovladimir quantificationofmastcellsindifferentstagesofperiodontaldisease AT lestarevicsnezana quantificationofmastcellsindifferentstagesofperiodontaldisease AT đorđevicnadica quantificationofmastcellsindifferentstagesofperiodontaldisease |