Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet
Because low-carbohydrate diets are effective strategies to improve insulin resistance, the hallmark of type 2 diabetes, the purpose of reporting these clinical cases was to reveal the meaningful changes observed in 90 days of low-carbohydrate (LC) ketogenic dietary intervention in female type 2 diab...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/8681959 |
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| author | Chase M. Walton Katelyn Perry Richard H. Hart Steven L. Berry Benjamin T. Bikman |
| author_facet | Chase M. Walton Katelyn Perry Richard H. Hart Steven L. Berry Benjamin T. Bikman |
| author_sort | Chase M. Walton |
| collection | DOAJ |
| description | Because low-carbohydrate diets are effective strategies to improve insulin resistance, the hallmark of type 2 diabetes, the purpose of reporting these clinical cases was to reveal the meaningful changes observed in 90 days of low-carbohydrate (LC) ketogenic dietary intervention in female type 2 diabetics aged 18-45. Eleven women (BMI 36.3 kg/m2) who were recently diagnosed with type 2 diabetes based on HbA1c over 6.5% (8.9%) volunteered to participate in an intensive dietary intervention to limit dietary carbohydrates to under 30 grams daily for 90 days. The main outcome was to determine the degree of change in HbA1c, while secondary outcomes included body weight, blood pressure, and blood lipids. The volunteers lost significant weight (85.7±3.2 kg to 76.7±2.8 kg) and lowered systolic (134.0±1.6 to 123.3±1.1 mmHg) and diastolic (89.9±1.3 to 82.6±1.0 mmHg) blood pressure. HbA1c dropped to 5.6%. Most blood lipids were significantly altered, including HDL cholesterol (43.1±4.4 to 52.3±3.3 mg/dl), triglycerides (177.0±19.8 to 92.1±8.7 mg/dl), and the TG : HDL ratio (4.7±0.8 to 1.9±0.2). LDL cholesterol was not significantly different. AST and ALT, plasma markers of liver health, were reported for eight patients and revealed no significant changes. These findings indicate that a short-term intervention emphasizing protein and fat at the expense of dietary carbohydrate functionally reversed the diabetes diagnosis, as defined by HbA1c. Furthermore, the intervention lowered body weight and blood pressure, while eliciting favorable changes in blood lipids. |
| format | Article |
| id | doaj-art-d2c5e89ec4304ffc83d7e2f5f1d08fd6 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d2c5e89ec4304ffc83d7e2f5f1d08fd62025-08-20T03:24:06ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/86819598681959Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic DietChase M. Walton0Katelyn Perry1Richard H. Hart2Steven L. Berry3Benjamin T. Bikman4Metabolism Research Lab, Department of Physiology and Developmental Biology, Brigham Young University, Provo UT, USAMetabolism Research Lab, Department of Physiology and Developmental Biology, Brigham Young University, Provo UT, USAInsulin IQ, Orem UT, USAInsulin IQ, Orem UT, USAMetabolism Research Lab, Department of Physiology and Developmental Biology, Brigham Young University, Provo UT, USABecause low-carbohydrate diets are effective strategies to improve insulin resistance, the hallmark of type 2 diabetes, the purpose of reporting these clinical cases was to reveal the meaningful changes observed in 90 days of low-carbohydrate (LC) ketogenic dietary intervention in female type 2 diabetics aged 18-45. Eleven women (BMI 36.3 kg/m2) who were recently diagnosed with type 2 diabetes based on HbA1c over 6.5% (8.9%) volunteered to participate in an intensive dietary intervention to limit dietary carbohydrates to under 30 grams daily for 90 days. The main outcome was to determine the degree of change in HbA1c, while secondary outcomes included body weight, blood pressure, and blood lipids. The volunteers lost significant weight (85.7±3.2 kg to 76.7±2.8 kg) and lowered systolic (134.0±1.6 to 123.3±1.1 mmHg) and diastolic (89.9±1.3 to 82.6±1.0 mmHg) blood pressure. HbA1c dropped to 5.6%. Most blood lipids were significantly altered, including HDL cholesterol (43.1±4.4 to 52.3±3.3 mg/dl), triglycerides (177.0±19.8 to 92.1±8.7 mg/dl), and the TG : HDL ratio (4.7±0.8 to 1.9±0.2). LDL cholesterol was not significantly different. AST and ALT, plasma markers of liver health, were reported for eight patients and revealed no significant changes. These findings indicate that a short-term intervention emphasizing protein and fat at the expense of dietary carbohydrate functionally reversed the diabetes diagnosis, as defined by HbA1c. Furthermore, the intervention lowered body weight and blood pressure, while eliciting favorable changes in blood lipids.http://dx.doi.org/10.1155/2019/8681959 |
| spellingShingle | Chase M. Walton Katelyn Perry Richard H. Hart Steven L. Berry Benjamin T. Bikman Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet Journal of Diabetes Research |
| title | Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet |
| title_full | Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet |
| title_fullStr | Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet |
| title_full_unstemmed | Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet |
| title_short | Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet |
| title_sort | improvement in glycemic and lipid profiles in type 2 diabetics with a 90 day ketogenic diet |
| url | http://dx.doi.org/10.1155/2019/8681959 |
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