Napsin A-specific T-cell clonotypes are associated with improved clinical outcomes in patients receiving checkpoint immunotherapy for metastatic non-small cell lung cancer

Napsin A-specific T-cell clonotypes are associated with improved clinical outcomes in patients receiving checkpoint immunotherapy for metastatic non-small cell lung cancer

Background Napsin A is normally expressed in human lung pneumocytes and is a highly expressed cancer antigen in lung adenocarcinoma. We examined whether T cells specific for Napsin A may play a role in immune checkpoint inhibitor (ICI)-mediated responses. We used bulk T-cell receptor (TCR) repertoir...

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Main Authors: Crystal Mackall, Heather Wakelee, Sylvia Lee, Keith D Eaton, Cristina Rodriguez, Rafael Santana-Davila, Joel W Neal, Natalie J Miller, Elena Sotillo, Tatyana Pisarenko, Eric Q Konnick, Christina Baik, Fangdi Sun, Renato G Martins, Sukhmani K Padda, Alex Camai, Viswam S Nair, A McGarry Houghton, Shin-Heng Chiou, Diane Tseng
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e011907.full
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