MicroRNA155 in non-small cell lung cancer: a potential therapeutic target
Lung cancer (LC) is the second most commonly diagnosed cancer among both men and women, and it stands as the leading cause of cancer-related mortality, characterized by high rates of morbidity and mortality. Among its subtypes, non-small cell lung cancer (NSCLC) is the most prevalent and one of the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1517995/full |
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| author | Xiangju Wei Xiangju Wei Xianmin Xiong Xianmin Xiong Ze Chen Bi Chen Cantang Zhang Wenhui Zhang |
| author_facet | Xiangju Wei Xiangju Wei Xianmin Xiong Xianmin Xiong Ze Chen Bi Chen Cantang Zhang Wenhui Zhang |
| author_sort | Xiangju Wei |
| collection | DOAJ |
| description | Lung cancer (LC) is the second most commonly diagnosed cancer among both men and women, and it stands as the leading cause of cancer-related mortality, characterized by high rates of morbidity and mortality. Among its subtypes, non-small cell lung cancer (NSCLC) is the most prevalent and one of the most challenging malignant tumors to treat. To date, various therapeutic approaches, including surgery, radiotherapy, and chemotherapy, have been employed in the management of lung cancer; however, due to its aggressive nature, the survival rates remain low. Consequently, exploring novel treatment strategies is of paramount importance. MicroRNAs (miRNAs), a large family of non-coding RNAs, play crucial roles in regulating several key biological processes, including cell proliferation, differentiation, inflammation, and apoptosis. Among these, microRNA155(miR-155) is one of the most conserved and versatile miRNAs, predominantly overexpressed in various diseases, including malignant tumors. This review elucidates the biological functions and roles of miR-155 in NSCLC and discusses its potential significance as a therapeutic target for future research directions and clinical applications. |
| format | Article |
| id | doaj-art-d2bc68dfed2449708372fd5c20aa03dd |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-d2bc68dfed2449708372fd5c20aa03dd2025-02-03T05:11:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15179951517995MicroRNA155 in non-small cell lung cancer: a potential therapeutic targetXiangju Wei0Xiangju Wei1Xianmin Xiong2Xianmin Xiong3Ze Chen4Bi Chen5Cantang Zhang6Wenhui Zhang7The First Clinical College, Xuzhou Medical University, Xuzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaThe First Clinical College, Xuzhou Medical University, Xuzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaThe First Clinical College, Xuzhou Medical University, Xuzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaLung cancer (LC) is the second most commonly diagnosed cancer among both men and women, and it stands as the leading cause of cancer-related mortality, characterized by high rates of morbidity and mortality. Among its subtypes, non-small cell lung cancer (NSCLC) is the most prevalent and one of the most challenging malignant tumors to treat. To date, various therapeutic approaches, including surgery, radiotherapy, and chemotherapy, have been employed in the management of lung cancer; however, due to its aggressive nature, the survival rates remain low. Consequently, exploring novel treatment strategies is of paramount importance. MicroRNAs (miRNAs), a large family of non-coding RNAs, play crucial roles in regulating several key biological processes, including cell proliferation, differentiation, inflammation, and apoptosis. Among these, microRNA155(miR-155) is one of the most conserved and versatile miRNAs, predominantly overexpressed in various diseases, including malignant tumors. This review elucidates the biological functions and roles of miR-155 in NSCLC and discusses its potential significance as a therapeutic target for future research directions and clinical applications.https://www.frontiersin.org/articles/10.3389/fonc.2025.1517995/fullmicroRNAmicroRNA155non-small cell lung cancerimmune responseoncogenic |
| spellingShingle | Xiangju Wei Xiangju Wei Xianmin Xiong Xianmin Xiong Ze Chen Bi Chen Cantang Zhang Wenhui Zhang MicroRNA155 in non-small cell lung cancer: a potential therapeutic target Frontiers in Oncology microRNA microRNA155 non-small cell lung cancer immune response oncogenic |
| title | MicroRNA155 in non-small cell lung cancer: a potential therapeutic target |
| title_full | MicroRNA155 in non-small cell lung cancer: a potential therapeutic target |
| title_fullStr | MicroRNA155 in non-small cell lung cancer: a potential therapeutic target |
| title_full_unstemmed | MicroRNA155 in non-small cell lung cancer: a potential therapeutic target |
| title_short | MicroRNA155 in non-small cell lung cancer: a potential therapeutic target |
| title_sort | microrna155 in non small cell lung cancer a potential therapeutic target |
| topic | microRNA microRNA155 non-small cell lung cancer immune response oncogenic |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1517995/full |
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