The integration of spear and shield: a panoramic analysis of the blood circulation-promoting and hemostatic effects of Panax notoginseng
Abstract Panax notoginseng is a widely used herb in traditional Chinese medicine renowned for its unique dual functionality in promoting blood circulation and stopping bleeding. However, the specific active components and the molecular mechanisms underlying the seemingly contradictory effects of P....
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-025-01100-6 |
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| author | Xinyue Zhang Chengxian Li Guoyun Wang Opoku Bonsu Francis Hongda Wang Aomei Sun Han Wu Xintong Yang Pengzhi Dong Wenke Zheng Qilong Wang Junhua Zhang |
| author_facet | Xinyue Zhang Chengxian Li Guoyun Wang Opoku Bonsu Francis Hongda Wang Aomei Sun Han Wu Xintong Yang Pengzhi Dong Wenke Zheng Qilong Wang Junhua Zhang |
| author_sort | Xinyue Zhang |
| collection | DOAJ |
| description | Abstract Panax notoginseng is a widely used herb in traditional Chinese medicine renowned for its unique dual functionality in promoting blood circulation and stopping bleeding. However, the specific active components and the molecular mechanisms underlying the seemingly contradictory effects of P. notoginseng remain unclear. This article reviews the literature on P. notoginseng focusing on its use in conditions including cardiovascular diseases, promoting blood circulation, and hemostasis. It provides a panoramic view of the regulatory roles of the different active components of P. notoginseng in maintaining vascular homeostasis, inflammatory responses, and coagulation-fibrinolysis during blood-activating/hemostatic conditions. By summarizing the pharmacological effects of P. notoginseng as reported by other studies, we have conducted a preliminary exploration of the medicinal basis and mechanisms that underlie its seemingly contradictory blood-activating and hemostatic effects. This research lays the groundwork for future studies into exploring the underlying mechanisms of P. notoginseng in "stopping bleeding without causing stasis and promoting blood circulation without harming the blood," and its application in preventing and treating cardiovascular diseases. Graphical abstract |
| format | Article |
| id | doaj-art-d2bb65faf3ac4cf89f8e61d92941067d |
| institution | OA Journals |
| issn | 1749-8546 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj-art-d2bb65faf3ac4cf89f8e61d92941067d2025-08-20T02:00:08ZengBMCChinese Medicine1749-85462025-05-0120112810.1186/s13020-025-01100-6The integration of spear and shield: a panoramic analysis of the blood circulation-promoting and hemostatic effects of Panax notoginsengXinyue Zhang0Chengxian Li1Guoyun Wang2Opoku Bonsu Francis3Hongda Wang4Aomei Sun5Han Wu6Xintong Yang7Pengzhi Dong8Wenke Zheng9Qilong Wang10Junhua Zhang11Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineAbstract Panax notoginseng is a widely used herb in traditional Chinese medicine renowned for its unique dual functionality in promoting blood circulation and stopping bleeding. However, the specific active components and the molecular mechanisms underlying the seemingly contradictory effects of P. notoginseng remain unclear. This article reviews the literature on P. notoginseng focusing on its use in conditions including cardiovascular diseases, promoting blood circulation, and hemostasis. It provides a panoramic view of the regulatory roles of the different active components of P. notoginseng in maintaining vascular homeostasis, inflammatory responses, and coagulation-fibrinolysis during blood-activating/hemostatic conditions. By summarizing the pharmacological effects of P. notoginseng as reported by other studies, we have conducted a preliminary exploration of the medicinal basis and mechanisms that underlie its seemingly contradictory blood-activating and hemostatic effects. This research lays the groundwork for future studies into exploring the underlying mechanisms of P. notoginseng in "stopping bleeding without causing stasis and promoting blood circulation without harming the blood," and its application in preventing and treating cardiovascular diseases. Graphical abstracthttps://doi.org/10.1186/s13020-025-01100-6Panax notoginsengCardiovascular diseasesCirculate bloodStop bleeding |
| spellingShingle | Xinyue Zhang Chengxian Li Guoyun Wang Opoku Bonsu Francis Hongda Wang Aomei Sun Han Wu Xintong Yang Pengzhi Dong Wenke Zheng Qilong Wang Junhua Zhang The integration of spear and shield: a panoramic analysis of the blood circulation-promoting and hemostatic effects of Panax notoginseng Chinese Medicine Panax notoginseng Cardiovascular diseases Circulate blood Stop bleeding |
| title | The integration of spear and shield: a panoramic analysis of the blood circulation-promoting and hemostatic effects of Panax notoginseng |
| title_full | The integration of spear and shield: a panoramic analysis of the blood circulation-promoting and hemostatic effects of Panax notoginseng |
| title_fullStr | The integration of spear and shield: a panoramic analysis of the blood circulation-promoting and hemostatic effects of Panax notoginseng |
| title_full_unstemmed | The integration of spear and shield: a panoramic analysis of the blood circulation-promoting and hemostatic effects of Panax notoginseng |
| title_short | The integration of spear and shield: a panoramic analysis of the blood circulation-promoting and hemostatic effects of Panax notoginseng |
| title_sort | integration of spear and shield a panoramic analysis of the blood circulation promoting and hemostatic effects of panax notoginseng |
| topic | Panax notoginseng Cardiovascular diseases Circulate blood Stop bleeding |
| url | https://doi.org/10.1186/s13020-025-01100-6 |
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