Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model

Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model

Abstract Background Parkinson’s disease (PD) is characterised by degeneration of ventral midbrain dopaminergic (DA) neurons and abnormal deposition of α-synuclein (α-syn) in neurons. Activation of the innate immune pathogen recognition receptor toll-like receptor 2 (TLR2) is associated with exacerba...

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Bibliographic Details
Main Authors: Fiona Weiss, Laura Hughes, Yuhong Fu, Cedric Bardy, Glenda M. Halliday, Nicolas Dzamko
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Translational Neurodegeneration
Subjects:
Parkinson’s disease
Toll-like receptor 2
Alpha-synuclein
Astrocyte
Lysosome
Online Access:https://doi.org/10.1186/s40035-024-00448-3
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