Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical Center
Purpose This retrospective study examined the factors influencing clinical outcomes and mortality in patients with Fournier's Gangrene (FG). The medical history, diagnostic procedures, treatment approaches, complications, and mortality factors associated with FG were analyzed. Materials and Met...
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Korean Association of Urogenital Tract Infection and Inflammation
2023-08-01
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| Series: | Urogenital Tract Infection |
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| Online Access: | http://euti.org/upload/pdf/uti-18-2-64.pdf |
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| author | Woo Seop Seong Byeong Jin Kang A Reum Kim Kyung Hwan Kim Hong Koo Ha |
| author_facet | Woo Seop Seong Byeong Jin Kang A Reum Kim Kyung Hwan Kim Hong Koo Ha |
| author_sort | Woo Seop Seong |
| collection | DOAJ |
| description | Purpose This retrospective study examined the factors influencing clinical outcomes and mortality in patients with Fournier's Gangrene (FG). The medical history, diagnostic procedures, treatment approaches, complications, and mortality factors associated with FG were analyzed. Materials and Methods This study retrospectively analyzed the medical records of 40 patients with FG treated over 10 years. The collected data included the patient demographics, comorbidities, vital signs, laboratory tests, Fournier’s Gangrene Severity Index (FGSI) scores, wound swab culture results, treatment approaches, and length of hospitalization. Results Among the patients with FG, diabetes mellitus and hypertension were the most common comorbidities. The hemodialysis dependence has been identified as a significant risk factor of mortality. In addition, septic shock and an FGSI >9 were associated with increased mortality. Escherichia coli was the most prevalent bacterium in wound swab cultures, and the presence of antibiotic-resistant bacteria was significantly higher in the non-survivors. Treatment involved broad-spectrum antibiotics, emergency surgical debridement, and subsequent adjustments based on culture results. Conclusions Early diagnosis and prompt initiation of treatment are essential for improving the outcomes of patients with FG. Hemodialysis dependency, septic shock, FGSI scores, and the presence of antibiotic-resistant bacteria are important factors associated with mortality in patients with FG. Further research will be needed to validate these findings and explore adjunctive therapies to enhance the patient outcomes and improve FG management. |
| format | Article |
| id | doaj-art-d2b2a3f29fcb4325bfadb1f29eec145a |
| institution | Kabale University |
| issn | 2465-8243 2465-8510 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Korean Association of Urogenital Tract Infection and Inflammation |
| record_format | Article |
| series | Urogenital Tract Infection |
| spelling | doaj-art-d2b2a3f29fcb4325bfadb1f29eec145a2025-08-20T03:32:11ZengKorean Association of Urogenital Tract Infection and InflammationUrogenital Tract Infection2465-82432465-85102023-08-01182646910.14777/uti.2023.18.2.64402Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical CenterWoo Seop Seong0Byeong Jin Kang1A Reum Kim2Kyung Hwan Kim3Hong Koo Ha4Department of Urology, Pusan National University Hospital, Busan, KoreaDepartment of Urology, Pusan National University Hospital, Busan, KoreaDivision of Infectious Diseases, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, KoreaDepartment of Urology, Pusan National University Hospital, Busan, KoreaDepartment of Urology, Pusan National University Hospital, Busan, KoreaPurpose This retrospective study examined the factors influencing clinical outcomes and mortality in patients with Fournier's Gangrene (FG). The medical history, diagnostic procedures, treatment approaches, complications, and mortality factors associated with FG were analyzed. Materials and Methods This study retrospectively analyzed the medical records of 40 patients with FG treated over 10 years. The collected data included the patient demographics, comorbidities, vital signs, laboratory tests, Fournier’s Gangrene Severity Index (FGSI) scores, wound swab culture results, treatment approaches, and length of hospitalization. Results Among the patients with FG, diabetes mellitus and hypertension were the most common comorbidities. The hemodialysis dependence has been identified as a significant risk factor of mortality. In addition, septic shock and an FGSI >9 were associated with increased mortality. Escherichia coli was the most prevalent bacterium in wound swab cultures, and the presence of antibiotic-resistant bacteria was significantly higher in the non-survivors. Treatment involved broad-spectrum antibiotics, emergency surgical debridement, and subsequent adjustments based on culture results. Conclusions Early diagnosis and prompt initiation of treatment are essential for improving the outcomes of patients with FG. Hemodialysis dependency, septic shock, FGSI scores, and the presence of antibiotic-resistant bacteria are important factors associated with mortality in patients with FG. Further research will be needed to validate these findings and explore adjunctive therapies to enhance the patient outcomes and improve FG management.http://euti.org/upload/pdf/uti-18-2-64.pdffournier's gangreneseptic shockantibiotic resistancehemodialysis |
| spellingShingle | Woo Seop Seong Byeong Jin Kang A Reum Kim Kyung Hwan Kim Hong Koo Ha Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical Center Urogenital Tract Infection fournier's gangrene septic shock antibiotic resistance hemodialysis |
| title | Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical Center |
| title_full | Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical Center |
| title_fullStr | Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical Center |
| title_full_unstemmed | Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical Center |
| title_short | Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical Center |
| title_sort | fournier s gangrene a 10 year clinical experience at a tertiary academic medical center |
| topic | fournier's gangrene septic shock antibiotic resistance hemodialysis |
| url | http://euti.org/upload/pdf/uti-18-2-64.pdf |
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