The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer
Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine.Aim: The purpose of this sudy was to...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Tehran
2023-01-01
|
| Series: | Sport Sciences and Health Research |
| Subjects: | |
| Online Access: | https://sshr.ut.ac.ir/article_92544_9dad87edc5032c0b1fe268dc4169393c.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850223943677378560 |
|---|---|
| author | Shahin Heydari Khadijeh Irandoust Morteza Taheri |
| author_facet | Shahin Heydari Khadijeh Irandoust Morteza Taheri |
| author_sort | Shahin Heydari |
| collection | DOAJ |
| description | Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine.Aim: The purpose of this sudy was to investigate the effect of 8 weeks of quercetin supplementation and intermittent exercise on protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in rats with colon cancer.Material and Methods: Tewenty-four rats were randomly assigned into four groups including quercetin (n=6), exercise (n=6), quercetin + exercise (n=6) and control group (n=6). Colon cancer induction was provided with the use of 1,2-dimethylhydrazine for 8 weeks and daily quercetin supplementation of 50 mg/kg body weight of mice by Gavagene method. Exercise protocol was performed 5 sessions per week with intensity of 60-70%, maximum speed of 23 m/min with 2-min rest in 8 weeks. ANOVA was used to analyze data. The level of significance was set at P<0.05.Results: It was suggested that there was a significant difference in protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in all groups (P<0.05). Furthermore, it was also indicated that Muc5Ac levels was significantly higher in the quercetin+ exercise group other than pther groups (P<0.05).Conclusions: It was concluded that intermittent exercise and quercetin supplementation would increase the levels of Muc5Ac and Muc4 proteins in the large intestine of mice with colon cancer. |
| format | Article |
| id | doaj-art-d2b0d003d01e4b8fa0d2bad28abc3e1c |
| institution | OA Journals |
| issn | 2981-0205 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Sport Sciences and Health Research |
| spelling | doaj-art-d2b0d003d01e4b8fa0d2bad28abc3e1c2025-08-20T02:05:46ZengUniversity of TehranSport Sciences and Health Research2981-02052023-01-01151132210.22059/sshr.2023.357150.108192544The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancerShahin Heydari0Khadijeh Irandoust1Morteza Taheri2Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran.Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran.Department of Behavioural and Cognitive Sciences in Sport, Faculty of Sport Science and Health, University of Tehran, Tehran, Iran.Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine.Aim: The purpose of this sudy was to investigate the effect of 8 weeks of quercetin supplementation and intermittent exercise on protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in rats with colon cancer.Material and Methods: Tewenty-four rats were randomly assigned into four groups including quercetin (n=6), exercise (n=6), quercetin + exercise (n=6) and control group (n=6). Colon cancer induction was provided with the use of 1,2-dimethylhydrazine for 8 weeks and daily quercetin supplementation of 50 mg/kg body weight of mice by Gavagene method. Exercise protocol was performed 5 sessions per week with intensity of 60-70%, maximum speed of 23 m/min with 2-min rest in 8 weeks. ANOVA was used to analyze data. The level of significance was set at P<0.05.Results: It was suggested that there was a significant difference in protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in all groups (P<0.05). Furthermore, it was also indicated that Muc5Ac levels was significantly higher in the quercetin+ exercise group other than pther groups (P<0.05).Conclusions: It was concluded that intermittent exercise and quercetin supplementation would increase the levels of Muc5Ac and Muc4 proteins in the large intestine of mice with colon cancer.https://sshr.ut.ac.ir/article_92544_9dad87edc5032c0b1fe268dc4169393c.pdfintermittent exercisemuc4muc5acpolyphosphatequercetin supplement |
| spellingShingle | Shahin Heydari Khadijeh Irandoust Morteza Taheri The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer Sport Sciences and Health Research intermittent exercise muc4 muc5ac polyphosphate quercetin supplement |
| title | The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer |
| title_full | The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer |
| title_fullStr | The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer |
| title_full_unstemmed | The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer |
| title_short | The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer |
| title_sort | effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of muc5ac muc4 and polyphosphate in rats with colon cancer |
| topic | intermittent exercise muc4 muc5ac polyphosphate quercetin supplement |
| url | https://sshr.ut.ac.ir/article_92544_9dad87edc5032c0b1fe268dc4169393c.pdf |
| work_keys_str_mv | AT shahinheydari theeffectof8weeksofquercetinsupplementationandintermittentexerciseongeneexpressionofmuc5acmuc4andpolyphosphateinratswithcoloncancer AT khadijehirandoust theeffectof8weeksofquercetinsupplementationandintermittentexerciseongeneexpressionofmuc5acmuc4andpolyphosphateinratswithcoloncancer AT mortezataheri theeffectof8weeksofquercetinsupplementationandintermittentexerciseongeneexpressionofmuc5acmuc4andpolyphosphateinratswithcoloncancer AT shahinheydari effectof8weeksofquercetinsupplementationandintermittentexerciseongeneexpressionofmuc5acmuc4andpolyphosphateinratswithcoloncancer AT khadijehirandoust effectof8weeksofquercetinsupplementationandintermittentexerciseongeneexpressionofmuc5acmuc4andpolyphosphateinratswithcoloncancer AT mortezataheri effectof8weeksofquercetinsupplementationandintermittentexerciseongeneexpressionofmuc5acmuc4andpolyphosphateinratswithcoloncancer |