Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China
Mpox, a zoonotic disease caused by the mpox virus (MPXV), has seen a significant shift in its epidemiological status since 2022, evolving from an initial local outbreak to a global epidemic. This recent outbreak of MPXV mainly emerged in several European and American countries and subsequently sprea...
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2025-01-01
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| author | Yin Song Yong Yan Jingyu Xu Shencong Lv Ganglin Ren Yamei Zhou Wanchen Song Rui Ge Peihua Xu Guoying Zhu Zhongwen Chen |
| author_facet | Yin Song Yong Yan Jingyu Xu Shencong Lv Ganglin Ren Yamei Zhou Wanchen Song Rui Ge Peihua Xu Guoying Zhu Zhongwen Chen |
| author_sort | Yin Song |
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| description | Mpox, a zoonotic disease caused by the mpox virus (MPXV), has seen a significant shift in its epidemiological status since 2022, evolving from an initial local outbreak to a global epidemic. This recent outbreak of MPXV mainly emerged in several European and American countries and subsequently spread to over 100 countries and regions worldwide. The rapid evolution of MPXV, coupled with increased international interactions, has led to a gradual rise in mpox cases in certain regions of Asia, mostly involving MPXV clade II and its branch strains. In contrast, the more pathogenic and clinically severe MPXV clade Ib has been relatively rare, with no reports in China to date. Here, we analyzed the whole gene sequence of imported MPXV clade Ib variant from the first infection case detected in China. Through whole genome sequencing, we successfully obtained a full-length MPXV genome of 195,405 base pairs (bp). Phylogenetic analysis revealed that the genetic sequence of the MPXV in this case was predominantly clustered with MPXV clade Ib sequences previously reported from multiple African and European countries. Compared with the MPXV clade Ib reference strain DQ011155.1, there are 127 nucleotide alterations and 57 amino acid mutations in the MPXV genome of this case. Given that the MPXV clade Ib has started to appear in China, we must pay more attention to the prevention of and control measures for the spread of mpox. |
| format | Article |
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| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-d2b04add37e64c88987ff9a1ba325d252025-01-24T13:44:55ZengMDPI AGPathogens2076-08172025-01-0114110210.3390/pathogens14010102Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in ChinaYin Song0Yong Yan1Jingyu Xu2Shencong Lv3Ganglin Ren4Yamei Zhou5Wanchen Song6Rui Ge7Peihua Xu8Guoying Zhu9Zhongwen Chen10Jiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaDepartment of Microbiology, Haiyan Center for Disease Control and Prevention, Haiyan, Jiaxing 314300, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaDepartment of Microbiology, Haiyan Center for Disease Control and Prevention, Haiyan, Jiaxing 314300, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, ChinaMpox, a zoonotic disease caused by the mpox virus (MPXV), has seen a significant shift in its epidemiological status since 2022, evolving from an initial local outbreak to a global epidemic. This recent outbreak of MPXV mainly emerged in several European and American countries and subsequently spread to over 100 countries and regions worldwide. The rapid evolution of MPXV, coupled with increased international interactions, has led to a gradual rise in mpox cases in certain regions of Asia, mostly involving MPXV clade II and its branch strains. In contrast, the more pathogenic and clinically severe MPXV clade Ib has been relatively rare, with no reports in China to date. Here, we analyzed the whole gene sequence of imported MPXV clade Ib variant from the first infection case detected in China. Through whole genome sequencing, we successfully obtained a full-length MPXV genome of 195,405 base pairs (bp). Phylogenetic analysis revealed that the genetic sequence of the MPXV in this case was predominantly clustered with MPXV clade Ib sequences previously reported from multiple African and European countries. Compared with the MPXV clade Ib reference strain DQ011155.1, there are 127 nucleotide alterations and 57 amino acid mutations in the MPXV genome of this case. Given that the MPXV clade Ib has started to appear in China, we must pay more attention to the prevention of and control measures for the spread of mpox.https://www.mdpi.com/2076-0817/14/1/102mpox viruswhole genome sequencingphylogenetic analysisgene mutation analysis |
| spellingShingle | Yin Song Yong Yan Jingyu Xu Shencong Lv Ganglin Ren Yamei Zhou Wanchen Song Rui Ge Peihua Xu Guoying Zhu Zhongwen Chen Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China Pathogens mpox virus whole genome sequencing phylogenetic analysis gene mutation analysis |
| title | Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China |
| title_full | Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China |
| title_fullStr | Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China |
| title_full_unstemmed | Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China |
| title_short | Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China |
| title_sort | complete genome sequence analysis of the first imported mpox virus clade ib variant in china |
| topic | mpox virus whole genome sequencing phylogenetic analysis gene mutation analysis |
| url | https://www.mdpi.com/2076-0817/14/1/102 |
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