Deciphering the role of MFGE8 in lactation using CRISPR-CAS9 based gene editing in Buffalo mammary epithelial cells

Deciphering the role of MFGE8 in lactation using CRISPR-CAS9 based gene editing in Buffalo mammary epithelial cells

Abstract Milk fat globule EGF factor 8 (MFGE8) is a glycoprotein which plays a crucial role in mammary gland remodeling. Our group previously identified MFGE8 as a marker associated with high milk yielding cows. Here, we generated MFGE8 knock-out buffalo mammary epithelial cells (BuMEC) via CRISPR-c...

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Bibliographic Details
Main Authors: Preeti Vats, Rohit Kumar, Raghvendra Kumar, Jai K. Kaushik, Ashok K. Mohanty, Sudarshan Kumar
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Milk fat globule EGF factor 8
CRISPR-Cas9
Buffalo mammary epithelial cells
Lactation biology
Mammary gland
Online Access:https://doi.org/10.1038/s41598-025-00155-7
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https://doi.org/10.1038/s41598-025-00155-7

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