Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy
Atypical femoral fractures (AFFs) are rare fractures usually associated with medications that can ultimately alter bone metabolism. Imatinib, a drug prescribed for treatment of chronic myeloid leukemia (CML), has been associated with altered bone homeostasis, however, with unknown clinical significa...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/crom/2081905 |
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| _version_ | 1850196378602438656 |
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| author | Ana C. Belzarena James L. Cook |
| author_facet | Ana C. Belzarena James L. Cook |
| author_sort | Ana C. Belzarena |
| collection | DOAJ |
| description | Atypical femoral fractures (AFFs) are rare fractures usually associated with medications that can ultimately alter bone metabolism. Imatinib, a drug prescribed for treatment of chronic myeloid leukemia (CML), has been associated with altered bone homeostasis, however, with unknown clinical significance. Here, we present the case of a 17-year-old female, with a diagnosis of CML undergoing chronic imatinib therapy, who developed an AFF treated successfully with prophylactic fixation with intramedullary nailing. Our case underscores the importance of prompt recognition of this entity to allow patients timely appropriate care, even at an early age. |
| format | Article |
| id | doaj-art-d2adb0e1c1a242e1909f2284664dfc86 |
| institution | OA Journals |
| issn | 2090-6714 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-d2adb0e1c1a242e1909f2284664dfc862025-08-20T02:13:27ZengWileyCase Reports in Oncological Medicine2090-67142025-01-01202510.1155/crom/2081905Atypical Femur Fracture in a Teenager on Chronic Imatinib TherapyAna C. Belzarena0James L. Cook1Missouri Orthopaedic InstituteOrthopaedic Surgery DepartmentAtypical femoral fractures (AFFs) are rare fractures usually associated with medications that can ultimately alter bone metabolism. Imatinib, a drug prescribed for treatment of chronic myeloid leukemia (CML), has been associated with altered bone homeostasis, however, with unknown clinical significance. Here, we present the case of a 17-year-old female, with a diagnosis of CML undergoing chronic imatinib therapy, who developed an AFF treated successfully with prophylactic fixation with intramedullary nailing. Our case underscores the importance of prompt recognition of this entity to allow patients timely appropriate care, even at an early age.http://dx.doi.org/10.1155/crom/2081905 |
| spellingShingle | Ana C. Belzarena James L. Cook Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy Case Reports in Oncological Medicine |
| title | Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy |
| title_full | Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy |
| title_fullStr | Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy |
| title_full_unstemmed | Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy |
| title_short | Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy |
| title_sort | atypical femur fracture in a teenager on chronic imatinib therapy |
| url | http://dx.doi.org/10.1155/crom/2081905 |
| work_keys_str_mv | AT anacbelzarena atypicalfemurfractureinateenageronchronicimatinibtherapy AT jameslcook atypicalfemurfractureinateenageronchronicimatinibtherapy |