Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?
ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct cu...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70073 |
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| author | Lukas L. Goede Patricia Zvarova Bahne H. Bahners Andreas Horn |
| author_facet | Lukas L. Goede Patricia Zvarova Bahne H. Bahners Andreas Horn |
| author_sort | Lukas L. Goede |
| collection | DOAJ |
| description | ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network. Levodopa improved motor performance more after tDCS than sham (41.72% vs. 31.52%; p < 0.001). In ten patients who later received DBS, the combined levodopa‐tDCS response accounted for DBS outcomes (p = 0.02). These findings suggest that targeted tDCS enhances levodopa effects and may be of potential use to optimize DBS candidate selection. |
| format | Article |
| id | doaj-art-d2acd7da2c2346808b706233f3a288ce |
| institution | DOAJ |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-d2acd7da2c2346808b706233f3a288ce2025-08-20T03:02:44ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-08-011281698170110.1002/acn3.70073Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?Lukas L. Goede0Patricia Zvarova1Bahne H. Bahners2Andreas Horn3Center for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, and Radiology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USACenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, and Radiology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USACenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, and Radiology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USACenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, and Radiology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USAABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network. Levodopa improved motor performance more after tDCS than sham (41.72% vs. 31.52%; p < 0.001). In ten patients who later received DBS, the combined levodopa‐tDCS response accounted for DBS outcomes (p = 0.02). These findings suggest that targeted tDCS enhances levodopa effects and may be of potential use to optimize DBS candidate selection.https://doi.org/10.1002/acn3.70073deep brain stimulationmovement disordersparkinson's diseasetranscranial direct current stimulation |
| spellingShingle | Lukas L. Goede Patricia Zvarova Bahne H. Bahners Andreas Horn Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? Annals of Clinical and Translational Neurology deep brain stimulation movement disorders parkinson's disease transcranial direct current stimulation |
| title | Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? |
| title_full | Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? |
| title_fullStr | Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? |
| title_full_unstemmed | Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? |
| title_short | Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? |
| title_sort | patient selection in deep brain stimulation a role for transcranial direct current stimulation to enhance the levodopa challenge |
| topic | deep brain stimulation movement disorders parkinson's disease transcranial direct current stimulation |
| url | https://doi.org/10.1002/acn3.70073 |
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