Learning and memory function in young people with and without perinatal HIV in England.
Learning and memory are important for successful education and career progression. We assess these functions in young people (YP) with perinatal HIV (PHIV) (with or without a previous AIDS-defining illness) and a comparable group of HIV-negative YP. 234 PHIV and 68 HIV-negative YP completed 9 tests;...
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Public Library of Science (PLoS)
2022-01-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0273645&type=printable |
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| author | Alejandro Arenas-Pinto Ali Judd Diane Melvin Marthe Le Prevost Caroline Foster Kate Sturgeon Alan Winston Lindsay C Thompson Diana M Gibb Hannah Castro Adolescents and Adults Living with Perinatal HIV (AALPHI) Steering Committee |
| author_facet | Alejandro Arenas-Pinto Ali Judd Diane Melvin Marthe Le Prevost Caroline Foster Kate Sturgeon Alan Winston Lindsay C Thompson Diana M Gibb Hannah Castro Adolescents and Adults Living with Perinatal HIV (AALPHI) Steering Committee |
| author_sort | Alejandro Arenas-Pinto |
| collection | DOAJ |
| description | Learning and memory are important for successful education and career progression. We assess these functions in young people (YP) with perinatal HIV (PHIV) (with or without a previous AIDS-defining illness) and a comparable group of HIV-negative YP. 234 PHIV and 68 HIV-negative YP completed 9 tests; 5 National Institutes of Health (NIH) Toolbox tests (2 executive function, 1 speed of information processing, 2 memory); 2 Hopkins Verbal Learning Test Revised (HVLT-R) (learning (L), delayed recall (R)), and 2 verbal application measures. Z-scores for each test were calculated using normative data and averaged by domain where appropriate. The effect of predictors on test scores in the three domains with the lowest z-scores were analysed using linear regression. 139(59%) and 48(71%) PHIV and HIV-negative YP were female, 202(86%) and 52(76%) Black, and median age was 19 [17, 21] and 18 [16, 21] years respectively. 55(24%) PHIV had a previous Center for Disease Control and Prevention (CDC) class C AIDS-defining diagnosis (PHIV/C). For HVLT-R, there was a trend towards PHIV/C YP having the lowest mean z-scores (L -1.5 (95% CI -1.8,-1.2), R -1.7 (-2.0,-1.4)) followed by PHIV without a CDC C diagnosis (L -1.3 (-1.4,-1.1), R -1.4 (-1.5,-1.2)) and then the HIV-negative group (L -1.0 (-1.3,-0.7), R -1.1 (-1.3,-0.8)); all were greater than 1 SD below the reference mean. The same trend was seen for verbal application measures; however, z-scores were within 1 SD below the reference mean. NIH Toolbox tests were similar for all groups. In multivariable analyses PHIV/C and Black ethnicity predicted lower HVLT-R scores. Black ethnicity also predicted lower executive function scores, however each year increase in age predicted higher scores. In conclusion, cognitive performance in verbal learning and recall fell below population normative scores, and was more pronounced in PHIV/C, supporting wider findings that earlier antiretroviral therapy initiation, before the occurrence of AIDS-defining conditions, may protect aspects of cognitive development. |
| format | Article |
| id | doaj-art-d2ac173374e84df799265c2ef5cef491 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-d2ac173374e84df799265c2ef5cef4912025-08-20T03:25:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027364510.1371/journal.pone.0273645Learning and memory function in young people with and without perinatal HIV in England.Alejandro Arenas-PintoAli JuddDiane MelvinMarthe Le PrevostCaroline FosterKate SturgeonAlan WinstonLindsay C ThompsonDiana M GibbHannah CastroAdolescents and Adults Living with Perinatal HIV (AALPHI) Steering CommitteeLearning and memory are important for successful education and career progression. We assess these functions in young people (YP) with perinatal HIV (PHIV) (with or without a previous AIDS-defining illness) and a comparable group of HIV-negative YP. 234 PHIV and 68 HIV-negative YP completed 9 tests; 5 National Institutes of Health (NIH) Toolbox tests (2 executive function, 1 speed of information processing, 2 memory); 2 Hopkins Verbal Learning Test Revised (HVLT-R) (learning (L), delayed recall (R)), and 2 verbal application measures. Z-scores for each test were calculated using normative data and averaged by domain where appropriate. The effect of predictors on test scores in the three domains with the lowest z-scores were analysed using linear regression. 139(59%) and 48(71%) PHIV and HIV-negative YP were female, 202(86%) and 52(76%) Black, and median age was 19 [17, 21] and 18 [16, 21] years respectively. 55(24%) PHIV had a previous Center for Disease Control and Prevention (CDC) class C AIDS-defining diagnosis (PHIV/C). For HVLT-R, there was a trend towards PHIV/C YP having the lowest mean z-scores (L -1.5 (95% CI -1.8,-1.2), R -1.7 (-2.0,-1.4)) followed by PHIV without a CDC C diagnosis (L -1.3 (-1.4,-1.1), R -1.4 (-1.5,-1.2)) and then the HIV-negative group (L -1.0 (-1.3,-0.7), R -1.1 (-1.3,-0.8)); all were greater than 1 SD below the reference mean. The same trend was seen for verbal application measures; however, z-scores were within 1 SD below the reference mean. NIH Toolbox tests were similar for all groups. In multivariable analyses PHIV/C and Black ethnicity predicted lower HVLT-R scores. Black ethnicity also predicted lower executive function scores, however each year increase in age predicted higher scores. In conclusion, cognitive performance in verbal learning and recall fell below population normative scores, and was more pronounced in PHIV/C, supporting wider findings that earlier antiretroviral therapy initiation, before the occurrence of AIDS-defining conditions, may protect aspects of cognitive development.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0273645&type=printable |
| spellingShingle | Alejandro Arenas-Pinto Ali Judd Diane Melvin Marthe Le Prevost Caroline Foster Kate Sturgeon Alan Winston Lindsay C Thompson Diana M Gibb Hannah Castro Adolescents and Adults Living with Perinatal HIV (AALPHI) Steering Committee Learning and memory function in young people with and without perinatal HIV in England. PLoS ONE |
| title | Learning and memory function in young people with and without perinatal HIV in England. |
| title_full | Learning and memory function in young people with and without perinatal HIV in England. |
| title_fullStr | Learning and memory function in young people with and without perinatal HIV in England. |
| title_full_unstemmed | Learning and memory function in young people with and without perinatal HIV in England. |
| title_short | Learning and memory function in young people with and without perinatal HIV in England. |
| title_sort | learning and memory function in young people with and without perinatal hiv in england |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0273645&type=printable |
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