Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair
The increasing demand of advanced biomedical materials for bone repair and regeneration has spurred significant research in recent years. While traditional hydrogels offer promising biocompatibility and easy fabrication, their application in bone reconstruction is often impeded by inadequate structu...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-04-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202400462 |
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| author | Guanghui Gu Youyin Xu Peng He Chenxu Li Shuqing Chen Gang Wei Yongming Xi |
| author_facet | Guanghui Gu Youyin Xu Peng He Chenxu Li Shuqing Chen Gang Wei Yongming Xi |
| author_sort | Guanghui Gu |
| collection | DOAJ |
| description | The increasing demand of advanced biomedical materials for bone repair and regeneration has spurred significant research in recent years. While traditional hydrogels offer promising biocompatibility and easy fabrication, their application in bone reconstruction is often impeded by inadequate structural integrity and biological functions. Graphene oxide (GO) has emerged as a transformative additive, renowned for its exceptional mechanical and chemical properties, as well as its ability to enhance the structural integrity of hydrogels. In this study, the incorporation of GO into chitosan (CS) hydrogels is investigated, achieving bioinspired hydrogels with enhanced mechanical strength and stability, which are crucial for supporting bone regeneration. Additionally, self‐assembled synthetic peptide nanofibers (PNFs) are employed to enhance biocompatibility and facilitate biomimetic mineralization of the bioinspired hydrogels, a critical process for effective bone remodeling. This innovative composite hydrogel not only achieves biomimetic mineralization but also exhibits osteogenic, pro‐angiogenic, and antioxidant properties essential for bone repair. This novel method takes advantage of the distinctive properties of GO, PNFs, and biomass hydrogels, providing a robust and effective material solution with the potential to significantly advance the field of bone tissue engineering. |
| format | Article |
| id | doaj-art-d2ab8f6e8ec44995b4a27b221b5ce79f |
| institution | OA Journals |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-d2ab8f6e8ec44995b4a27b221b5ce79f2025-08-20T02:16:55ZengWiley-VCHSmall Structures2688-40622025-04-0164n/an/a10.1002/sstr.202400462Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone RepairGuanghui Gu0Youyin Xu1Peng He2Chenxu Li3Shuqing Chen4Gang Wei5Yongming Xi6Department of Spinal Surgery The Affiliated Hospital of Qingdao University Qingdao 266071 P. R. ChinaCollege of Chemistry & Chemical Engineering Qingdao University Qingdao 266071 ChinaCollege of Chemistry & Chemical Engineering Qingdao University Qingdao 266071 ChinaDepartment of Spinal Surgery The Affiliated Hospital of Qingdao University Qingdao 266071 P. R. ChinaDepartment of Spinal Surgery The Affiliated Hospital of Qingdao University Qingdao 266071 P. R. ChinaCollege of Chemistry & Chemical Engineering Qingdao University Qingdao 266071 ChinaDepartment of Spinal Surgery The Affiliated Hospital of Qingdao University Qingdao 266071 P. R. ChinaThe increasing demand of advanced biomedical materials for bone repair and regeneration has spurred significant research in recent years. While traditional hydrogels offer promising biocompatibility and easy fabrication, their application in bone reconstruction is often impeded by inadequate structural integrity and biological functions. Graphene oxide (GO) has emerged as a transformative additive, renowned for its exceptional mechanical and chemical properties, as well as its ability to enhance the structural integrity of hydrogels. In this study, the incorporation of GO into chitosan (CS) hydrogels is investigated, achieving bioinspired hydrogels with enhanced mechanical strength and stability, which are crucial for supporting bone regeneration. Additionally, self‐assembled synthetic peptide nanofibers (PNFs) are employed to enhance biocompatibility and facilitate biomimetic mineralization of the bioinspired hydrogels, a critical process for effective bone remodeling. This innovative composite hydrogel not only achieves biomimetic mineralization but also exhibits osteogenic, pro‐angiogenic, and antioxidant properties essential for bone repair. This novel method takes advantage of the distinctive properties of GO, PNFs, and biomass hydrogels, providing a robust and effective material solution with the potential to significantly advance the field of bone tissue engineering.https://doi.org/10.1002/sstr.202400462bioinspired hydrogelsbone tissue engineeringmultifunctionpeptide nanofibersself‐assembly |
| spellingShingle | Guanghui Gu Youyin Xu Peng He Chenxu Li Shuqing Chen Gang Wei Yongming Xi Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair Small Structures bioinspired hydrogels bone tissue engineering multifunction peptide nanofibers self‐assembly |
| title | Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair |
| title_full | Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair |
| title_fullStr | Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair |
| title_full_unstemmed | Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair |
| title_short | Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair |
| title_sort | bioinspired composite hydrogels with osteogenic angiogenic and antioxidant properties for enhanced bone repair |
| topic | bioinspired hydrogels bone tissue engineering multifunction peptide nanofibers self‐assembly |
| url | https://doi.org/10.1002/sstr.202400462 |
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