Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot Ulcers
Boron-containing compounds (BCCs) have been proposed for the treatment of diabetes and its complications. Recent studies have reported an improvement in the design and development of pharmaceutical formulations (often gels) containing boric acid applied to the foot ulcers of humans diagnosed with di...
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MDPI AG
2025-03-01
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| Online Access: | https://www.mdpi.com/2218-0532/93/1/14 |
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| author | Marvin A. Soriano-Ursúa Marlet Martínez-Archundia Ahmet Kilic Teresa Pérez-Capistran Miriam A. Hernández-Zamora Juan E. López-Ramos Eunice D. Farfán-García |
| author_facet | Marvin A. Soriano-Ursúa Marlet Martínez-Archundia Ahmet Kilic Teresa Pérez-Capistran Miriam A. Hernández-Zamora Juan E. López-Ramos Eunice D. Farfán-García |
| author_sort | Marvin A. Soriano-Ursúa |
| collection | DOAJ |
| description | Boron-containing compounds (BCCs) have been proposed for the treatment of diabetes and its complications. Recent studies have reported an improvement in the design and development of pharmaceutical formulations (often gels) containing boric acid applied to the foot ulcers of humans diagnosed with diabetes. The proposed mechanisms of action of boric acid include antimicrobial effects, the modulation of inflammation and metabolism, and the induction of cell differentiation. On the other hand, recent studies have suggested that boronic acids are potent antibacterial and antifungal compounds, effective modulators of inflammation, and inducers of vascular regeneration as well as inducers of healing, and they confer attractive properties such as adhesion, interaction, and the formation of complexes in formulations. Moreover, only a handful of studies conducted in animals have suggested the effective role of some BCCs as potent enhancers of wound healing, including their actions on induced and/or infected wounds in animals with disrupted metabolism. Also, it should be mentioned that no strong interactions between boric acid and the boronic acids present in formulations have been described. The developed combination could act as an additive and complementary therapy in the treatment of diabetic ulcers in humans. Further studies are required to support the hypothesis that this combination acts through diverse mechanisms to improve healing while avoiding or limiting a local or disseminated infection. Furthermore, the safety of BCCs used for foot ulcers should be established, as should the role of these formulations as a complementary therapy in current protocols for treating patients with diabetic foot ulcers. |
| format | Article |
| id | doaj-art-d2a930e22def44a4bcaf50dd5f234e49 |
| institution | Kabale University |
| issn | 0036-8709 2218-0532 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Scientia Pharmaceutica |
| spelling | doaj-art-d2a930e22def44a4bcaf50dd5f234e492025-08-20T03:44:05ZengMDPI AGScientia Pharmaceutica0036-87092218-05322025-03-019311410.3390/scipharm93010014Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot UlcersMarvin A. Soriano-Ursúa0Marlet Martínez-Archundia1Ahmet Kilic2Teresa Pérez-Capistran3Miriam A. Hernández-Zamora4Juan E. López-Ramos5Eunice D. Farfán-García6Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, México City 11340, MexicoEscuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, México City 11340, MexicoDepartment of Chemistry, Faculty of Arts and Science, Harran University, Sanliurfa 63200, TurkeyEscuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, México City 11340, MexicoEscuela Nacional de Ciencias Biológicas, Manuel Carpio y Plutarco Elías Calles s/n, Miguel Hidalgo, México City 11350, MexicoCentro de Estudios Científicos y Tecnológicos del IPN, No. 18. Boulevard El Bote s/n, Zacatecas 98160, MexicoEscuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, México City 11340, MexicoBoron-containing compounds (BCCs) have been proposed for the treatment of diabetes and its complications. Recent studies have reported an improvement in the design and development of pharmaceutical formulations (often gels) containing boric acid applied to the foot ulcers of humans diagnosed with diabetes. The proposed mechanisms of action of boric acid include antimicrobial effects, the modulation of inflammation and metabolism, and the induction of cell differentiation. On the other hand, recent studies have suggested that boronic acids are potent antibacterial and antifungal compounds, effective modulators of inflammation, and inducers of vascular regeneration as well as inducers of healing, and they confer attractive properties such as adhesion, interaction, and the formation of complexes in formulations. Moreover, only a handful of studies conducted in animals have suggested the effective role of some BCCs as potent enhancers of wound healing, including their actions on induced and/or infected wounds in animals with disrupted metabolism. Also, it should be mentioned that no strong interactions between boric acid and the boronic acids present in formulations have been described. The developed combination could act as an additive and complementary therapy in the treatment of diabetic ulcers in humans. Further studies are required to support the hypothesis that this combination acts through diverse mechanisms to improve healing while avoiding or limiting a local or disseminated infection. Furthermore, the safety of BCCs used for foot ulcers should be established, as should the role of these formulations as a complementary therapy in current protocols for treating patients with diabetic foot ulcers.https://www.mdpi.com/2218-0532/93/1/14boricboroniculcergelwound healinginflammation |
| spellingShingle | Marvin A. Soriano-Ursúa Marlet Martínez-Archundia Ahmet Kilic Teresa Pérez-Capistran Miriam A. Hernández-Zamora Juan E. López-Ramos Eunice D. Farfán-García Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot Ulcers Scientia Pharmaceutica boric boronic ulcer gel wound healing inflammation |
| title | Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot Ulcers |
| title_full | Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot Ulcers |
| title_fullStr | Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot Ulcers |
| title_full_unstemmed | Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot Ulcers |
| title_short | Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot Ulcers |
| title_sort | formulations with boric acid or aryl organoboron compounds for treating diabetic foot ulcers |
| topic | boric boronic ulcer gel wound healing inflammation |
| url | https://www.mdpi.com/2218-0532/93/1/14 |
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