PROTEIN PHOSPHATASE 1В IN THE PATHOGENESIS OF LARYNGEAL AND HYPOPHARYNGEAL CANCER
To predict the development and clinical course of squamous cell head and neck carcinoma (SCHNC), we studied the level of protein phosphatase 1B (РРМ1В) using the proteomic analysis. Verification of the results of proteomic analysis by ELISA showed that the level of РРМ1В in blood serum of patients w...
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Russian Academy of Sciences, Tomsk National Research Medical Center
2017-09-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/570 |
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| author | G. V. Kakurina D. E. Kulbakin O. V. Cheremisina I. V. Kondakova E. L. Choynzonov |
| author_facet | G. V. Kakurina D. E. Kulbakin O. V. Cheremisina I. V. Kondakova E. L. Choynzonov |
| author_sort | G. V. Kakurina |
| collection | DOAJ |
| description | To predict the development and clinical course of squamous cell head and neck carcinoma (SCHNC), we studied the level of protein phosphatase 1B (РРМ1В) using the proteomic analysis. Verification of the results of proteomic analysis by ELISA showed that the level of РРМ1В in blood serum of patients with SCHNC depended on the disease stage. The level of РРМ1В in the blood serum of patients with stage T1N0M0 cancer was higher than that observed in the control group and in patients with chronic hyperplastic laryngitis. In tumor tissue, the level of РРМ1В was associated with the size of the primary tumor and the presence of metastases. In tumor tissue, the level of РРМ1В was also higher in patients with stage T1N0M0 than in patients with chronic hyperplastic laryngitis. The data obtained indicate that the level of РРМ1В can be used for early detection and prediction of the clinical course of SCHNC. Further studies with larger cohorts of patients are required to evaluate the prognostic significance of the РРМ1В level. |
| format | Article |
| id | doaj-art-d2a91add9efa42b9979efe7c8b1cf75a |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2017-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-d2a91add9efa42b9979efe7c8b1cf75a2025-08-20T02:59:10ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682017-09-01164495310.21294/1814-4861-2017-16-4-49-53468PROTEIN PHOSPHATASE 1В IN THE PATHOGENESIS OF LARYNGEAL AND HYPOPHARYNGEAL CANCERG. V. Kakurina0D. E. Kulbakin1O. V. Cheremisina2I. V. Kondakova3E. L. Choynzonov4Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.To predict the development and clinical course of squamous cell head and neck carcinoma (SCHNC), we studied the level of protein phosphatase 1B (РРМ1В) using the proteomic analysis. Verification of the results of proteomic analysis by ELISA showed that the level of РРМ1В in blood serum of patients with SCHNC depended on the disease stage. The level of РРМ1В in the blood serum of patients with stage T1N0M0 cancer was higher than that observed in the control group and in patients with chronic hyperplastic laryngitis. In tumor tissue, the level of РРМ1В was associated with the size of the primary tumor and the presence of metastases. In tumor tissue, the level of РРМ1В was also higher in patients with stage T1N0M0 than in patients with chronic hyperplastic laryngitis. The data obtained indicate that the level of РРМ1В can be used for early detection and prediction of the clinical course of SCHNC. Further studies with larger cohorts of patients are required to evaluate the prognostic significance of the РРМ1В level.https://www.siboncoj.ru/jour/article/view/570squamous cell head and neck carcinomaearly detectionprognosischronic hyperplastic laryngitis and pharyngitisepithelial dysplasiaprotein phosphatase 1b |
| spellingShingle | G. V. Kakurina D. E. Kulbakin O. V. Cheremisina I. V. Kondakova E. L. Choynzonov PROTEIN PHOSPHATASE 1В IN THE PATHOGENESIS OF LARYNGEAL AND HYPOPHARYNGEAL CANCER Сибирский онкологический журнал squamous cell head and neck carcinoma early detection prognosis chronic hyperplastic laryngitis and pharyngitis epithelial dysplasia protein phosphatase 1b |
| title | PROTEIN PHOSPHATASE 1В IN THE PATHOGENESIS OF LARYNGEAL AND HYPOPHARYNGEAL CANCER |
| title_full | PROTEIN PHOSPHATASE 1В IN THE PATHOGENESIS OF LARYNGEAL AND HYPOPHARYNGEAL CANCER |
| title_fullStr | PROTEIN PHOSPHATASE 1В IN THE PATHOGENESIS OF LARYNGEAL AND HYPOPHARYNGEAL CANCER |
| title_full_unstemmed | PROTEIN PHOSPHATASE 1В IN THE PATHOGENESIS OF LARYNGEAL AND HYPOPHARYNGEAL CANCER |
| title_short | PROTEIN PHOSPHATASE 1В IN THE PATHOGENESIS OF LARYNGEAL AND HYPOPHARYNGEAL CANCER |
| title_sort | protein phosphatase 1в in the pathogenesis of laryngeal and hypopharyngeal cancer |
| topic | squamous cell head and neck carcinoma early detection prognosis chronic hyperplastic laryngitis and pharyngitis epithelial dysplasia protein phosphatase 1b |
| url | https://www.siboncoj.ru/jour/article/view/570 |
| work_keys_str_mv | AT gvkakurina proteinphosphatase1vinthepathogenesisoflaryngealandhypopharyngealcancer AT dekulbakin proteinphosphatase1vinthepathogenesisoflaryngealandhypopharyngealcancer AT ovcheremisina proteinphosphatase1vinthepathogenesisoflaryngealandhypopharyngealcancer AT ivkondakova proteinphosphatase1vinthepathogenesisoflaryngealandhypopharyngealcancer AT elchoynzonov proteinphosphatase1vinthepathogenesisoflaryngealandhypopharyngealcancer |