Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism.

Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism.

Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(Δpepc) ), which was only achievable when malate, a...

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Main Authors: Janet Storm, Sonal Sethia, Gavin J Blackburn, Achuthanunni Chokkathukalam, David G Watson, Rainer Breitling, Graham H Coombs, Sylke Müller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1003876
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