The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tract
Abstract The mucosal system serves as the primary barrier against respiratory diseases and plays a crucial role in combating viral infections through mucosal immunity. The resident microbial community constitutes the main component of the mucosal system and exerts a significant inhibitory impact on...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06433-2 |
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| author | Xinyue Li Maohua Chen Tingting Chen Lingxin Xie Qian Luo Xinyue Fan Yan Yin Siqin Meng Zhixing Jin Yonglin He Yao Wen |
| author_facet | Xinyue Li Maohua Chen Tingting Chen Lingxin Xie Qian Luo Xinyue Fan Yan Yin Siqin Meng Zhixing Jin Yonglin He Yao Wen |
| author_sort | Xinyue Li |
| collection | DOAJ |
| description | Abstract The mucosal system serves as the primary barrier against respiratory diseases and plays a crucial role in combating viral infections through mucosal immunity. The resident microbial community constitutes the main component of the mucosal system and exerts a significant inhibitory impact on the invasion of exogenous agents. However, the precise relationship between resident microbiota, mucosal immunity, and viral infections remains incomplete. This review aims to summarize the regulatory interactions between the resident microbiota of the mucosal system and innate immune components such as mucosal immunity and trained immunity. By clarifying these complex relationships, this review seeks to identify potential targets for augmenting respiratory disease prevention strategies and developing novel vaccine formulations. Furthermore, we propose the possibility of integrating the fields of microbiome-based therapeutics and vaccine development to create multifunctional vaccine formulations capable of targeting mucosal immunity induction. Such an approach holds great potential in offering novel pathways and strategies for the prevention and treatment of respiratory diseases. |
| format | Article |
| id | doaj-art-d2a62f0917744a6ebc006050ba4fd7e8 |
| institution | OA Journals |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-d2a62f0917744a6ebc006050ba4fd7e82025-08-20T02:10:53ZengBMCJournal of Translational Medicine1479-58762025-04-0123112110.1186/s12967-025-06433-2The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tractXinyue Li0Maohua Chen1Tingting Chen2Lingxin Xie3Qian Luo4Xinyue Fan5Yan Yin6Siqin Meng7Zhixing Jin8Yonglin He9Yao Wen10Pathogen Biology and Immunology Laboratory, Lab Teaching & Management Center, Chongqing Medical UniversityCollege of Medical Informatics, Chongqing Medical UniversityPathogen Biology and Immunology Laboratory, Lab Teaching & Management Center, Chongqing Medical UniversityPathogen Biology and Immunology Laboratory, Lab Teaching & Management Center, Chongqing Medical UniversityPathogen Biology and Immunology Laboratory, Lab Teaching & Management Center, Chongqing Medical UniversityPathogen Biology and Immunology Laboratory, Lab Teaching & Management Center, Chongqing Medical UniversityPathogen Biology and Immunology Laboratory, Lab Teaching & Management Center, Chongqing Medical UniversityPathogen Biology and Immunology Laboratory, Lab Teaching & Management Center, Chongqing Medical UniversityPathogen Biology and Immunology Laboratory, Lab Teaching & Management Center, Chongqing Medical UniversityDepartment of Pathogenic Biology, College of Basic Medicine, Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical UniversityAbstract The mucosal system serves as the primary barrier against respiratory diseases and plays a crucial role in combating viral infections through mucosal immunity. The resident microbial community constitutes the main component of the mucosal system and exerts a significant inhibitory impact on the invasion of exogenous agents. However, the precise relationship between resident microbiota, mucosal immunity, and viral infections remains incomplete. This review aims to summarize the regulatory interactions between the resident microbiota of the mucosal system and innate immune components such as mucosal immunity and trained immunity. By clarifying these complex relationships, this review seeks to identify potential targets for augmenting respiratory disease prevention strategies and developing novel vaccine formulations. Furthermore, we propose the possibility of integrating the fields of microbiome-based therapeutics and vaccine development to create multifunctional vaccine formulations capable of targeting mucosal immunity induction. Such an approach holds great potential in offering novel pathways and strategies for the prevention and treatment of respiratory diseases.https://doi.org/10.1186/s12967-025-06433-2Mucosal immuneMicrobiotaViral infectionTrained immunityRespiratory tract |
| spellingShingle | Xinyue Li Maohua Chen Tingting Chen Lingxin Xie Qian Luo Xinyue Fan Yan Yin Siqin Meng Zhixing Jin Yonglin He Yao Wen The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tract Journal of Translational Medicine Mucosal immune Microbiota Viral infection Trained immunity Respiratory tract |
| title | The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tract |
| title_full | The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tract |
| title_fullStr | The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tract |
| title_full_unstemmed | The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tract |
| title_short | The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tract |
| title_sort | intricate interplay among microbiota mucosal immunity and viral infection in the respiratory tract |
| topic | Mucosal immune Microbiota Viral infection Trained immunity Respiratory tract |
| url | https://doi.org/10.1186/s12967-025-06433-2 |
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