Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: a case report
Hypotrichosis simplex of the scalp (HSS) is a clinically rare monogenic autosomal dominant disorder associated with variants in the gene CDSN, which encodes the desmosome protein corneodesmosin. Although studies have reported that some medications can improve the symptoms of hair loss in HSS, there...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1491870/full |
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| author | Mingyue Zhuang Mingyue Zhuang Yonglong Xu Shiyi Zhong Ziyuan Tian Qingwu Liu Dingquan Yang |
| author_facet | Mingyue Zhuang Mingyue Zhuang Yonglong Xu Shiyi Zhong Ziyuan Tian Qingwu Liu Dingquan Yang |
| author_sort | Mingyue Zhuang |
| collection | DOAJ |
| description | Hypotrichosis simplex of the scalp (HSS) is a clinically rare monogenic autosomal dominant disorder associated with variants in the gene CDSN, which encodes the desmosome protein corneodesmosin. Although studies have reported that some medications can improve the symptoms of hair loss in HSS, there is still a lack of definitive and effective treatments for this disease. We report a familial case of HSS in an 8-year-old male child diagnosed with HSS caused by a mutation in CDSN, who was treated with botanical extracts in combination with minoxidil, which resulted in significant hair growth after two treatments. This is the first study describing the improvement of clinical symptoms of HSS with oral botanical extracts. This suggests that botanical extracts in combination with minoxidil may be a therapeutic approach for HSS in the clinic. |
| format | Article |
| id | doaj-art-d29faa4699e74f9db9a2bb33e7e46dee |
| institution | Kabale University |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-d29faa4699e74f9db9a2bb33e7e46dee2025-01-20T07:19:45ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-01-011510.3389/fgene.2024.14918701491870Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: a case reportMingyue Zhuang0Mingyue Zhuang1Yonglong Xu2Shiyi Zhong3Ziyuan Tian4Qingwu Liu5Dingquan Yang6School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, ChinaSchool of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, ChinaHypotrichosis simplex of the scalp (HSS) is a clinically rare monogenic autosomal dominant disorder associated with variants in the gene CDSN, which encodes the desmosome protein corneodesmosin. Although studies have reported that some medications can improve the symptoms of hair loss in HSS, there is still a lack of definitive and effective treatments for this disease. We report a familial case of HSS in an 8-year-old male child diagnosed with HSS caused by a mutation in CDSN, who was treated with botanical extracts in combination with minoxidil, which resulted in significant hair growth after two treatments. This is the first study describing the improvement of clinical symptoms of HSS with oral botanical extracts. This suggests that botanical extracts in combination with minoxidil may be a therapeutic approach for HSS in the clinic.https://www.frontiersin.org/articles/10.3389/fgene.2024.1491870/fullbotanical extractshypotrichosis simplex of the scalphair diseasefamily genealogygenetic mutation |
| spellingShingle | Mingyue Zhuang Mingyue Zhuang Yonglong Xu Shiyi Zhong Ziyuan Tian Qingwu Liu Dingquan Yang Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: a case report Frontiers in Genetics botanical extracts hypotrichosis simplex of the scalp hair disease family genealogy genetic mutation |
| title | Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: a case report |
| title_full | Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: a case report |
| title_fullStr | Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: a case report |
| title_full_unstemmed | Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: a case report |
| title_short | Treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil: a case report |
| title_sort | treatment of hypotrichosis simplex of the scalp with the combination of botanic extracts and minoxidil a case report |
| topic | botanical extracts hypotrichosis simplex of the scalp hair disease family genealogy genetic mutation |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1491870/full |
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