A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration

The most recent revision of the World Health Organization (WHO) Classification of Tumours of Endocrine Organs introduced a new variant of follicular thyroid carcinoma (FTC). It is characterized by a “glomeruloid” architectural pattern of growth. We present a case of follicular tumor with glomeruloid...

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Main Authors: Daniela Cabibi, Andrea Mondello, Ada Maria Florena, Giulia Rimi, Antonino Giulio Giannone, Calogero Cipolla, Maria Rosaria Valerio, Giuseppa Graceffa
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Pathology
Online Access:http://dx.doi.org/10.1155/2021/1686025
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author Daniela Cabibi
Andrea Mondello
Ada Maria Florena
Giulia Rimi
Antonino Giulio Giannone
Calogero Cipolla
Maria Rosaria Valerio
Giuseppa Graceffa
author_facet Daniela Cabibi
Andrea Mondello
Ada Maria Florena
Giulia Rimi
Antonino Giulio Giannone
Calogero Cipolla
Maria Rosaria Valerio
Giuseppa Graceffa
author_sort Daniela Cabibi
collection DOAJ
description The most recent revision of the World Health Organization (WHO) Classification of Tumours of Endocrine Organs introduced a new variant of follicular thyroid carcinoma (FTC). It is characterized by a “glomeruloid” architectural pattern of growth. We present a case of follicular tumor with glomeruloid features, with Alcian Blue positive mucinous stromal degeneration in foci of questionable capsular microinvasion. At our knowledge, this the second case of glomeruloid follicular tumor in the literature and the first case in which Alcian Blue staining was used to investigate capsular invasion. Moreover, RAS mutation further supports that this is a variant of follicular tumor with uncertain malignant potential.
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issn 2090-6781
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language English
publishDate 2021-01-01
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series Case Reports in Pathology
spelling doaj-art-d29c55261f1e4d21933e9cc12a258c7a2025-08-20T02:19:43ZengWileyCase Reports in Pathology2090-67812090-679X2021-01-01202110.1155/2021/16860251686025A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous DegenerationDaniela Cabibi0Andrea Mondello1Ada Maria Florena2Giulia Rimi3Antonino Giulio Giannone4Calogero Cipolla5Maria Rosaria Valerio6Giuseppa Graceffa7Department of Sciences for the Promotion of Health and Mother and Child Care, Anatomic Pathology, University of Palermo, Via Giovanni Pascoli, 6, 90133 Palermo, ItalyDepartment of Sciences for the Promotion of Health and Mother and Child Care, Anatomic Pathology, University of Palermo, Via Giovanni Pascoli, 6, 90133 Palermo, ItalyDepartment of Sciences for the Promotion of Health and Mother and Child Care, Anatomic Pathology, University of Palermo, Via Giovanni Pascoli, 6, 90133 Palermo, ItalyDepartment of Sciences for the Promotion of Health and Mother and Child Care, Anatomic Pathology, University of Palermo, Via Giovanni Pascoli, 6, 90133 Palermo, ItalyDepartment of Sciences for the Promotion of Health and Mother and Child Care, Anatomic Pathology, University of Palermo, Via Giovanni Pascoli, 6, 90133 Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences, Via del Vespro 129, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences, Via del Vespro 129, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences, Via del Vespro 129, 90127 Palermo, ItalyThe most recent revision of the World Health Organization (WHO) Classification of Tumours of Endocrine Organs introduced a new variant of follicular thyroid carcinoma (FTC). It is characterized by a “glomeruloid” architectural pattern of growth. We present a case of follicular tumor with glomeruloid features, with Alcian Blue positive mucinous stromal degeneration in foci of questionable capsular microinvasion. At our knowledge, this the second case of glomeruloid follicular tumor in the literature and the first case in which Alcian Blue staining was used to investigate capsular invasion. Moreover, RAS mutation further supports that this is a variant of follicular tumor with uncertain malignant potential.http://dx.doi.org/10.1155/2021/1686025
spellingShingle Daniela Cabibi
Andrea Mondello
Ada Maria Florena
Giulia Rimi
Antonino Giulio Giannone
Calogero Cipolla
Maria Rosaria Valerio
Giuseppa Graceffa
A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
Case Reports in Pathology
title A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_full A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_fullStr A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_full_unstemmed A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_short A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
title_sort case of follicular tumor of uncertain malignant potential ft ump with glomeruloid features showing capsular mucinous degeneration
url http://dx.doi.org/10.1155/2021/1686025
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