Food intake enhances hippocampal sharp wave-ripples
Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about the body’s energy state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secre...
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| Format: | Article |
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eLife Sciences Publications Ltd
2025-04-01
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| Online Access: | https://elifesciences.org/articles/105059 |
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| author | Ekin Kaya Evan Wegienka Alexandra Akhtarzandi-Das Hanh Do Ada Eban-Rothschild Gideon Rothschild |
| author_facet | Ekin Kaya Evan Wegienka Alexandra Akhtarzandi-Das Hanh Do Ada Eban-Rothschild Gideon Rothschild |
| author_sort | Ekin Kaya |
| collection | DOAJ |
| description | Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about the body’s energy state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, and food-seeking behaviors. It has recently been found that the hippocampus, a brain region traditionally associated with memory and spatial navigation, is also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), which are high-frequency neural oscillations supporting memory consolidation and foraging decisions, have been shown to reduce peripheral glucose levels. However, whether SWRs are enhanced by recent feeding—when the need for glucose metabolism increases, and if so, whether feeding-dependent modulation of SWRs is communicated to other brain regions involved in metabolic regulation—remains unknown. To address these gaps, we recorded SWRs from the dorsal CA1 region of the hippocampus of mice during sleep sessions before and after consumption of meals of varying caloric values. We found that SWRs occurring during sleep are significantly enhanced following food intake, with the magnitude of enhancement being dependent on the caloric content of the meal. This pattern occurred under both food-deprived and ad libitum feeding conditions. Moreover, we demonstrate that GABAergic neurons in the lateral hypothalamus, which are known to regulate food intake, exhibit a robust SWR-triggered increase in activity. These findings identify the satiety state as a factor modulating SWRs and suggest that hippocampal-lateral hypothalamic communication is a potential mechanism by which SWRs could modulate peripheral metabolism and food intake. |
| format | Article |
| id | doaj-art-d29b58bcc757441f87f0b5b9639de7f5 |
| institution | DOAJ |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | eLife Sciences Publications Ltd |
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| spelling | doaj-art-d29b58bcc757441f87f0b5b9639de7f52025-08-20T03:06:43ZengeLife Sciences Publications LtdeLife2050-084X2025-04-011410.7554/eLife.105059Food intake enhances hippocampal sharp wave-ripplesEkin Kaya0https://orcid.org/0000-0001-9235-4954Evan Wegienka1Alexandra Akhtarzandi-Das2Hanh Do3Ada Eban-Rothschild4https://orcid.org/0000-0001-5816-1315Gideon Rothschild5https://orcid.org/0000-0002-9700-1020Department of Psychology, University of Michigan, Ann Arbor, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, United States; Kresge Hearing Research Institute and Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, United StatesEffective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about the body’s energy state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, and food-seeking behaviors. It has recently been found that the hippocampus, a brain region traditionally associated with memory and spatial navigation, is also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), which are high-frequency neural oscillations supporting memory consolidation and foraging decisions, have been shown to reduce peripheral glucose levels. However, whether SWRs are enhanced by recent feeding—when the need for glucose metabolism increases, and if so, whether feeding-dependent modulation of SWRs is communicated to other brain regions involved in metabolic regulation—remains unknown. To address these gaps, we recorded SWRs from the dorsal CA1 region of the hippocampus of mice during sleep sessions before and after consumption of meals of varying caloric values. We found that SWRs occurring during sleep are significantly enhanced following food intake, with the magnitude of enhancement being dependent on the caloric content of the meal. This pattern occurred under both food-deprived and ad libitum feeding conditions. Moreover, we demonstrate that GABAergic neurons in the lateral hypothalamus, which are known to regulate food intake, exhibit a robust SWR-triggered increase in activity. These findings identify the satiety state as a factor modulating SWRs and suggest that hippocampal-lateral hypothalamic communication is a potential mechanism by which SWRs could modulate peripheral metabolism and food intake.https://elifesciences.org/articles/105059sharp wave-rippleshippocampusmetabolismhypothalamusfeeding |
| spellingShingle | Ekin Kaya Evan Wegienka Alexandra Akhtarzandi-Das Hanh Do Ada Eban-Rothschild Gideon Rothschild Food intake enhances hippocampal sharp wave-ripples eLife sharp wave-ripples hippocampus metabolism hypothalamus feeding |
| title | Food intake enhances hippocampal sharp wave-ripples |
| title_full | Food intake enhances hippocampal sharp wave-ripples |
| title_fullStr | Food intake enhances hippocampal sharp wave-ripples |
| title_full_unstemmed | Food intake enhances hippocampal sharp wave-ripples |
| title_short | Food intake enhances hippocampal sharp wave-ripples |
| title_sort | food intake enhances hippocampal sharp wave ripples |
| topic | sharp wave-ripples hippocampus metabolism hypothalamus feeding |
| url | https://elifesciences.org/articles/105059 |
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