Importance of immune status for prognosis chronic borreliosis infections
Tendency to chronization of infectious process is characteristic of a current the Ixodes tick-borne borreliosis. Early identification of laboratory signs of risk of development of a chronic process of disease will allow to correct in due time therapy and to prevent a disease failure.Research objecti...
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| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/218 |
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| author | N. S. Minoranskaya A. N. Uskov P. V. Sarap |
| author_facet | N. S. Minoranskaya A. N. Uskov P. V. Sarap |
| author_sort | N. S. Minoranskaya |
| collection | DOAJ |
| description | Tendency to chronization of infectious process is characteristic of a current the Ixodes tick-borne borreliosis. Early identification of laboratory signs of risk of development of a chronic process of disease will allow to correct in due time therapy and to prevent a disease failure.Research objective: search of criteria for chronization in the retrospective analysis of the immune status of patients with various clinical forms of sharp ixodes tick-borne borreliosis.Materials and methods: clinical trials are executed at 161 patients with a chronic current and 420 patients with a sharp process of disease. Results of the retrospective analysis of the immune status and cytokines taking into account recovery and disease chronization are given.Results of research: predictive criteria of chronization of an erythema form of Ixodes tick-borne borreliosis were decrease in absolute quantity of lymphocytes, a phagocytic index, number of the phagocytic neutrophils, the raised level of the total IgM. Significant criteria of chronization of an illness after the ended non-erythema’s form of a disease were decrease in an expression of cytotoxic CD8+ of cells, decrease CD4+/CD8+ of cells and decrease in number the phagocytic neutrophils. For all clinical forms of a sharp process of Ixodes tick-borne borreliosis the increased synthesis interleukin-8 during the convalescence period at patients with the subsequent chronization of a disease was characteristic. Preservation of high level of interleukin-1β secretion and a neoplasm necrosis factor-α after the ended non-erythema’s form of an illness was predictive criterion of chronization of a disease. Characteristic of production cytokines at patients with the combined course of a borreliosis-encephalitis infection in the sharp period of a disease was high level of synthesis interleukin-4.Conclusion: adverse predictive criteria of development of a chronic process of Ixodes tick-borne borreliosis are failure of a phagocytic link to immune system, decrease in an expression of cytotoxic CD8+ of the cells, the increased synthesis interleukin-8 and interleukin-4. |
| format | Article |
| id | doaj-art-d293bb916ae1402390d3eca0c077a7df |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-d293bb916ae1402390d3eca0c077a7df2025-08-20T03:44:24ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0161354010.22625/2072-6732-2014-6-1-35-40232Importance of immune status for prognosis chronic borreliosis infectionsN. S. Minoranskaya0A. N. Uskov1P. V. Sarap2Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenetsky, Krasnoyarsk, RussiaScience Research Institute of Children’s Infections of FMBA of Russia, Saint-Petersburg, RussiaCity Clinical Emergency Hospital named after N.S. Karpovich, Krasnoyarsk, RussiaTendency to chronization of infectious process is characteristic of a current the Ixodes tick-borne borreliosis. Early identification of laboratory signs of risk of development of a chronic process of disease will allow to correct in due time therapy and to prevent a disease failure.Research objective: search of criteria for chronization in the retrospective analysis of the immune status of patients with various clinical forms of sharp ixodes tick-borne borreliosis.Materials and methods: clinical trials are executed at 161 patients with a chronic current and 420 patients with a sharp process of disease. Results of the retrospective analysis of the immune status and cytokines taking into account recovery and disease chronization are given.Results of research: predictive criteria of chronization of an erythema form of Ixodes tick-borne borreliosis were decrease in absolute quantity of lymphocytes, a phagocytic index, number of the phagocytic neutrophils, the raised level of the total IgM. Significant criteria of chronization of an illness after the ended non-erythema’s form of a disease were decrease in an expression of cytotoxic CD8+ of cells, decrease CD4+/CD8+ of cells and decrease in number the phagocytic neutrophils. For all clinical forms of a sharp process of Ixodes tick-borne borreliosis the increased synthesis interleukin-8 during the convalescence period at patients with the subsequent chronization of a disease was characteristic. Preservation of high level of interleukin-1β secretion and a neoplasm necrosis factor-α after the ended non-erythema’s form of an illness was predictive criterion of chronization of a disease. Characteristic of production cytokines at patients with the combined course of a borreliosis-encephalitis infection in the sharp period of a disease was high level of synthesis interleukin-4.Conclusion: adverse predictive criteria of development of a chronic process of Ixodes tick-borne borreliosis are failure of a phagocytic link to immune system, decrease in an expression of cytotoxic CD8+ of the cells, the increased synthesis interleukin-8 and interleukin-4.https://journal.niidi.ru/jofin/article/view/218chronic ixodes tick-borne borreliosisprognosisimmune statuscytokines |
| spellingShingle | N. S. Minoranskaya A. N. Uskov P. V. Sarap Importance of immune status for prognosis chronic borreliosis infections Журнал инфектологии chronic ixodes tick-borne borreliosis prognosis immune status cytokines |
| title | Importance of immune status for prognosis chronic borreliosis infections |
| title_full | Importance of immune status for prognosis chronic borreliosis infections |
| title_fullStr | Importance of immune status for prognosis chronic borreliosis infections |
| title_full_unstemmed | Importance of immune status for prognosis chronic borreliosis infections |
| title_short | Importance of immune status for prognosis chronic borreliosis infections |
| title_sort | importance of immune status for prognosis chronic borreliosis infections |
| topic | chronic ixodes tick-borne borreliosis prognosis immune status cytokines |
| url | https://journal.niidi.ru/jofin/article/view/218 |
| work_keys_str_mv | AT nsminoranskaya importanceofimmunestatusforprognosischronicborreliosisinfections AT anuskov importanceofimmunestatusforprognosischronicborreliosisinfections AT pvsarap importanceofimmunestatusforprognosischronicborreliosisinfections |