Criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantation
Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated death globally. Liver transplantation (LT) has emerged as a key treatment for patients with HCC, and the Milan criteria have been adopted as the cornerstone of the selection policy. To allow more patients to benefit from LT, a nu...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of the Liver
2025-02-01
|
| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2024-0323.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849761066664329216 |
|---|---|
| author | Meng Sha Jun Wang Jie Cao Zhi-Hui Zou Xiao-ye Qu Zhi-feng Xi Chuan Shen Ying Tong Jian-jun Zhang Seogsong Jeong Qiang Xia |
| author_facet | Meng Sha Jun Wang Jie Cao Zhi-Hui Zou Xiao-ye Qu Zhi-feng Xi Chuan Shen Ying Tong Jian-jun Zhang Seogsong Jeong Qiang Xia |
| author_sort | Meng Sha |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated death globally. Liver transplantation (LT) has emerged as a key treatment for patients with HCC, and the Milan criteria have been adopted as the cornerstone of the selection policy. To allow more patients to benefit from LT, a number of expanded criteria have been proposed, many of which use radiologic morphological characteristics with larger and more tumors as surrogates to predict outcomes. Other groups developed indices incorporating biological variables and dynamic markers of response to locoregional treatment. These expanded selection criteria achieved satisfactory results with limited liver supplies. In addition, a number of prognostic models have been developed using clinicopathological characteristics, imaging radiomics features, genetic data, and advanced techniques such as artificial intelligence. These models could improve prognostic estimation, establish surveillance strategies, and bolster long-term outcomes in patients with HCC. In this study, we reviewed the latest findings and achievements regarding the selection criteria and post-transplant prognostic models for LT in patients with HCC. |
| format | Article |
| id | doaj-art-d28a54f407fb46d4bbeef91659a9a52d |
| institution | DOAJ |
| issn | 2287-2728 2287-285X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj-art-d28a54f407fb46d4bbeef91659a9a52d2025-08-20T03:06:09ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2025-02-0131SupplS285S30010.3350/cmh.2024.03232009Criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantationMeng Sha0Jun Wang1Jie Cao2Zhi-Hui Zou3Xiao-ye Qu4Zhi-feng Xi5Chuan Shen6Ying Tong7Jian-jun Zhang8Seogsong Jeong9Qiang Xia10 Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Naval Military Medical University, Shanghai, China Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Biomedical Informatics, Korea University College of Medicine, Seoul, Korea Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaHepatocellular carcinoma (HCC) is a leading cause of cancer-associated death globally. Liver transplantation (LT) has emerged as a key treatment for patients with HCC, and the Milan criteria have been adopted as the cornerstone of the selection policy. To allow more patients to benefit from LT, a number of expanded criteria have been proposed, many of which use radiologic morphological characteristics with larger and more tumors as surrogates to predict outcomes. Other groups developed indices incorporating biological variables and dynamic markers of response to locoregional treatment. These expanded selection criteria achieved satisfactory results with limited liver supplies. In addition, a number of prognostic models have been developed using clinicopathological characteristics, imaging radiomics features, genetic data, and advanced techniques such as artificial intelligence. These models could improve prognostic estimation, establish surveillance strategies, and bolster long-term outcomes in patients with HCC. In this study, we reviewed the latest findings and achievements regarding the selection criteria and post-transplant prognostic models for LT in patients with HCC.http://e-cmh.org/upload/pdf/cmh-2024-0323.pdfhepatocellular carcinomaliver transplantationstandardsnomogram |
| spellingShingle | Meng Sha Jun Wang Jie Cao Zhi-Hui Zou Xiao-ye Qu Zhi-feng Xi Chuan Shen Ying Tong Jian-jun Zhang Seogsong Jeong Qiang Xia Criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantation Clinical and Molecular Hepatology hepatocellular carcinoma liver transplantation standards nomogram |
| title | Criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantation |
| title_full | Criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantation |
| title_fullStr | Criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantation |
| title_full_unstemmed | Criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantation |
| title_short | Criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantation |
| title_sort | criteria and prognostic models for patients with hepatocellular carcinoma undergoing liver transplantation |
| topic | hepatocellular carcinoma liver transplantation standards nomogram |
| url | http://e-cmh.org/upload/pdf/cmh-2024-0323.pdf |
| work_keys_str_mv | AT mengsha criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT junwang criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT jiecao criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT zhihuizou criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT xiaoyequ criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT zhifengxi criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT chuanshen criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT yingtong criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT jianjunzhang criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT seogsongjeong criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation AT qiangxia criteriaandprognosticmodelsforpatientswithhepatocellularcarcinomaundergoinglivertransplantation |