Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease with poor survival rates and limited treatment options. Upregulation of αvβ6 integrins within the alveolar epithelial cells is a characteristic feature of IPF and correlates with poor patient survival. The pro-fibrotic cytokin...

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Main Authors: Amanda L Tatler, Amanda T Goodwin, Olumide Gbolahan, Gauri Saini, Joanne Porte, Alison E John, Rachel L Clifford, Shelia M Violette, Paul H Weinreb, Helen Parfrey, Paul J Wolters, Jack Gauldie, Martin Kolb, Gisli Jenkins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0158047&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0158047&type=printable

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