Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation
The immune system plays an important role in the communication between the human body and the environment, in early development as well as in adulthood. Per se, research has shown that factors such as maternal stress and nutrition as well as maternal infections can activate the immune system in the...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/194396 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550520435245056 |
|---|---|
| author | Ksenia Musaelyan Martin Egeland Cathy Fernandes Carmine M. Pariante Patricia A. Zunszain Sandrine Thuret |
| author_facet | Ksenia Musaelyan Martin Egeland Cathy Fernandes Carmine M. Pariante Patricia A. Zunszain Sandrine Thuret |
| author_sort | Ksenia Musaelyan |
| collection | DOAJ |
| description | The immune system plays an important role in the communication between the human body and the environment, in early development as well as in adulthood. Per se, research has shown that factors such as maternal stress and nutrition as well as maternal infections can activate the immune system in the infant. A rising number of research studies have shown that activation of the immune system in early life can augment the risk of some psychiatric disorders in adulthood, such as schizophrenia and depression. The mechanisms of such a developmental programming effect are unknown; however some preliminary evidence is emerging in the literature, which suggests that adult hippocampal neurogenesis may be involved. A growing number of studies have shown that pre- and postnatal exposure to an inflammatory stimulus can modulate the number of proliferating and differentiating neural progenitors in the adult hippocampus, and this can have an effect on behaviours of relevance to psychiatric disorders. This review provides a summary of these studies and highlights the evidence supporting a neurogenic hypothesis of immune developmental programming. |
| format | Article |
| id | doaj-art-d2766a115b894f34b1c99575d1243378 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d2766a115b894f34b1c99575d12433782025-02-03T06:06:36ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/194396194396Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune ActivationKsenia Musaelyan0Martin Egeland1Cathy Fernandes2Carmine M. Pariante3Patricia A. Zunszain4Sandrine Thuret5Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King’s College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UKCentre for the Cellular Basis of Behaviour, Institute of Psychiatry, King’s College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UKMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, 16 De Crespigny Park, London SE5 8AF, UKCentre for the Cellular Basis of Behaviour, Institute of Psychiatry, King’s College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UKCentre for the Cellular Basis of Behaviour, Institute of Psychiatry, King’s College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UKCentre for the Cellular Basis of Behaviour, Institute of Psychiatry, King’s College London, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UKThe immune system plays an important role in the communication between the human body and the environment, in early development as well as in adulthood. Per se, research has shown that factors such as maternal stress and nutrition as well as maternal infections can activate the immune system in the infant. A rising number of research studies have shown that activation of the immune system in early life can augment the risk of some psychiatric disorders in adulthood, such as schizophrenia and depression. The mechanisms of such a developmental programming effect are unknown; however some preliminary evidence is emerging in the literature, which suggests that adult hippocampal neurogenesis may be involved. A growing number of studies have shown that pre- and postnatal exposure to an inflammatory stimulus can modulate the number of proliferating and differentiating neural progenitors in the adult hippocampus, and this can have an effect on behaviours of relevance to psychiatric disorders. This review provides a summary of these studies and highlights the evidence supporting a neurogenic hypothesis of immune developmental programming.http://dx.doi.org/10.1155/2014/194396 |
| spellingShingle | Ksenia Musaelyan Martin Egeland Cathy Fernandes Carmine M. Pariante Patricia A. Zunszain Sandrine Thuret Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation Neural Plasticity |
| title | Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation |
| title_full | Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation |
| title_fullStr | Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation |
| title_full_unstemmed | Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation |
| title_short | Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation |
| title_sort | modulation of adult hippocampal neurogenesis by early life environmental challenges triggering immune activation |
| url | http://dx.doi.org/10.1155/2014/194396 |
| work_keys_str_mv | AT kseniamusaelyan modulationofadulthippocampalneurogenesisbyearlylifeenvironmentalchallengestriggeringimmuneactivation AT martinegeland modulationofadulthippocampalneurogenesisbyearlylifeenvironmentalchallengestriggeringimmuneactivation AT cathyfernandes modulationofadulthippocampalneurogenesisbyearlylifeenvironmentalchallengestriggeringimmuneactivation AT carminempariante modulationofadulthippocampalneurogenesisbyearlylifeenvironmentalchallengestriggeringimmuneactivation AT patriciaazunszain modulationofadulthippocampalneurogenesisbyearlylifeenvironmentalchallengestriggeringimmuneactivation AT sandrinethuret modulationofadulthippocampalneurogenesisbyearlylifeenvironmentalchallengestriggeringimmuneactivation |