Designs of NKG2D-based immunotherapeutics for cancer

Designs of NKG2D-based immunotherapeutics for cancer

Natural killer group 2 D (NKG2D) receptor, one of the activation receptors on NK cells, has gained increasing attention in recent years because its ligands are widely expressed in most cancers. Naturally, NKG2D reacts to 8 different stress-induced ligands, MICA/B, and ULBP1-6. Despite being genomica...

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Bibliographic Details
Main Authors: Jianfeng Han, Youwei Wang, Godfrey Chi-Fung Chan, Wing Keung Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
NKG2D
immunotherapy
CAR-T therapy
NK cell therapy
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557644/full
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