Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a critical intracellular signaling pathway that is pivotal in various cellular functions. It is in senescence, survival, and growth under normal physiological and pathological conditions, including neoplasms. Additionally, this pathway...
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| Format: | Article |
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Springer
2025-05-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02471-w |
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| author | Neda Hedayati Mohamad Hosein Safari Yaser Eshaghi Milasi Samaneh Kahkesh Najma Farahani Seyedeh Mahdieh Khoshnazar Zahra Dorostgou Elmira Alaei Mina Alimohammadi Payman Rahimzadeh Afshin Taheriazam Mehrdad Hashemi |
| author_facet | Neda Hedayati Mohamad Hosein Safari Yaser Eshaghi Milasi Samaneh Kahkesh Najma Farahani Seyedeh Mahdieh Khoshnazar Zahra Dorostgou Elmira Alaei Mina Alimohammadi Payman Rahimzadeh Afshin Taheriazam Mehrdad Hashemi |
| author_sort | Neda Hedayati |
| collection | DOAJ |
| description | Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a critical intracellular signaling pathway that is pivotal in various cellular functions. It is in senescence, survival, and growth under normal physiological and pathological conditions, including neoplasms. Additionally, this pathway has been recognized as essential for the regulation of the cell cycle. Several previous studies have indicated that the PI3K/Akt signaling pathway can be influenced by various natural products, with resveratrol (3,4′,5-trihydroxy-trans-stilbene) being a particularly important phytoalexin polyphenol in this context. This review explores the impact of the PI3K/Akt signaling pathway on the initiation and advancement of various cancerous conditions and the potential of resveratrol to target this signaling mechanism. The review begins by summarizing the anti-tumor capabilities of resveratrol and then emphasizes the significant role of the PI3K/Akt signaling pathway in the progression of multiple malignancies. Finally, we discuss the therapeutic effects of resveratrol on human neoplasms, from brain cancers to gastrointestinal malignancies, through regulation of this signaling cascade. |
| format | Article |
| id | doaj-art-d273b7ce73a940edac12baa7c2a7ff83 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-d273b7ce73a940edac12baa7c2a7ff832025-08-20T03:09:20ZengSpringerDiscover Oncology2730-60112025-05-0116112410.1007/s12672-025-02471-wModulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunityNeda Hedayati0Mohamad Hosein Safari1Yaser Eshaghi Milasi2Samaneh Kahkesh3Najma Farahani4Seyedeh Mahdieh Khoshnazar5Zahra Dorostgou6Elmira Alaei7Mina Alimohammadi8Payman Rahimzadeh9Afshin Taheriazam10Mehrdad Hashemi11School of Medicine, Iran University of Medical SciencesDepartment of Internal Medicine, Faculty of Veterinary Medicine, University of TehranDepartment of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical SciencesFaculty of Science, Shahid Chamran University of AhvazFarhikhtegan Medical Convergent Sciences Research Center, TeMs. C., Islamic Azad UniversityGastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical SciencesDepartment of Biochemistry, Neyshabur Branch, Islamic Azad UniversitySchool of Medicine, Tehran University of Medical SciencesDepartment of Immunology, School of Medicine, Shahid Beheshti University of Medical SciencesSurgical Research Society (SRS), Students’ Scientific Research Center, Tehran University of Medical SciencesFarhikhtegan Medical Convergent Sciences Research Center, TeMs. C., Islamic Azad UniversityFarhikhtegan Medical Convergent Sciences Research Center, TeMs. C., Islamic Azad UniversityAbstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a critical intracellular signaling pathway that is pivotal in various cellular functions. It is in senescence, survival, and growth under normal physiological and pathological conditions, including neoplasms. Additionally, this pathway has been recognized as essential for the regulation of the cell cycle. Several previous studies have indicated that the PI3K/Akt signaling pathway can be influenced by various natural products, with resveratrol (3,4′,5-trihydroxy-trans-stilbene) being a particularly important phytoalexin polyphenol in this context. This review explores the impact of the PI3K/Akt signaling pathway on the initiation and advancement of various cancerous conditions and the potential of resveratrol to target this signaling mechanism. The review begins by summarizing the anti-tumor capabilities of resveratrol and then emphasizes the significant role of the PI3K/Akt signaling pathway in the progression of multiple malignancies. Finally, we discuss the therapeutic effects of resveratrol on human neoplasms, from brain cancers to gastrointestinal malignancies, through regulation of this signaling cascade.https://doi.org/10.1007/s12672-025-02471-wNeoplasmsPhosphatidylinositol 3-kinase signal transductionProto-oncogene protein AktResveratrol |
| spellingShingle | Neda Hedayati Mohamad Hosein Safari Yaser Eshaghi Milasi Samaneh Kahkesh Najma Farahani Seyedeh Mahdieh Khoshnazar Zahra Dorostgou Elmira Alaei Mina Alimohammadi Payman Rahimzadeh Afshin Taheriazam Mehrdad Hashemi Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity Discover Oncology Neoplasms Phosphatidylinositol 3-kinase signal transduction Proto-oncogene protein Akt Resveratrol |
| title | Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity |
| title_full | Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity |
| title_fullStr | Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity |
| title_full_unstemmed | Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity |
| title_short | Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity |
| title_sort | modulation of the pi3k akt signaling pathway by resveratrol in cancer molecular mechanisms and therapeutic opportunity |
| topic | Neoplasms Phosphatidylinositol 3-kinase signal transduction Proto-oncogene protein Akt Resveratrol |
| url | https://doi.org/10.1007/s12672-025-02471-w |
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