Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye.
Biological processes are intrinsically noisy, and yet, the result of development-like the species-specific size and shape of organs-is usually remarkably precise. This precision suggests the existence of mechanisms of feedback control that ensure that deviations from a target size are minimized. Sti...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002450&type=printable |
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| author | Tomas Navarro Antonella Iannini Marta Neto Alejandro Campoy-Lopez Javier Muñoz-García Paulo S Pereira Saúl Ares Fernando Casares |
| author_facet | Tomas Navarro Antonella Iannini Marta Neto Alejandro Campoy-Lopez Javier Muñoz-García Paulo S Pereira Saúl Ares Fernando Casares |
| author_sort | Tomas Navarro |
| collection | DOAJ |
| description | Biological processes are intrinsically noisy, and yet, the result of development-like the species-specific size and shape of organs-is usually remarkably precise. This precision suggests the existence of mechanisms of feedback control that ensure that deviations from a target size are minimized. Still, we have very limited understanding of how these mechanisms operate. Here, we investigate the problem of organ size precision using the Drosophila eye. The size of the adult eye depends on the rates at which eye progenitor cells grow and differentiate. We first find that the progenitor net growth rate results from the balance between their proliferation and apoptosis, with this latter contributing to determining both final eye size and its variability. In turn, apoptosis of progenitor cells is hampered by Dpp, a BMP2/4 signaling molecule transiently produced by early differentiating retinal cells. Our genetic and computational experiments show how the status of retinal differentiation is communicated to progenitors through the differentiation-dependent production of Dpp, which, by adjusting the rate of apoptosis, exerts a feedback control over the net growth of progenitors to reduce final eye size variability. |
| format | Article |
| id | doaj-art-d271aeb056014633b9d801f6cc38b7cd |
| institution | OA Journals |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-d271aeb056014633b9d801f6cc38b7cd2025-08-20T02:11:26ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852024-01-01221e300245010.1371/journal.pbio.3002450Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye.Tomas NavarroAntonella IanniniMarta NetoAlejandro Campoy-LopezJavier Muñoz-GarcíaPaulo S PereiraSaúl AresFernando CasaresBiological processes are intrinsically noisy, and yet, the result of development-like the species-specific size and shape of organs-is usually remarkably precise. This precision suggests the existence of mechanisms of feedback control that ensure that deviations from a target size are minimized. Still, we have very limited understanding of how these mechanisms operate. Here, we investigate the problem of organ size precision using the Drosophila eye. The size of the adult eye depends on the rates at which eye progenitor cells grow and differentiate. We first find that the progenitor net growth rate results from the balance between their proliferation and apoptosis, with this latter contributing to determining both final eye size and its variability. In turn, apoptosis of progenitor cells is hampered by Dpp, a BMP2/4 signaling molecule transiently produced by early differentiating retinal cells. Our genetic and computational experiments show how the status of retinal differentiation is communicated to progenitors through the differentiation-dependent production of Dpp, which, by adjusting the rate of apoptosis, exerts a feedback control over the net growth of progenitors to reduce final eye size variability.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002450&type=printable |
| spellingShingle | Tomas Navarro Antonella Iannini Marta Neto Alejandro Campoy-Lopez Javier Muñoz-García Paulo S Pereira Saúl Ares Fernando Casares Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye. PLoS Biology |
| title | Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye. |
| title_full | Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye. |
| title_fullStr | Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye. |
| title_full_unstemmed | Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye. |
| title_short | Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye. |
| title_sort | feedback control of organ size precision is mediated by bmp2 regulated apoptosis in the drosophila eye |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002450&type=printable |
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