Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trial

Background/Aims Small polyps are the most frequently detected lesions during colonoscopy, with an incomplete resection rate of 6.8% to 15.9%. This study aimed to improve small polyp cold snare resection radicality using submucosal contrast dye pre-lifting (PL+CSP). Methods This single-center, prospe...

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Main Authors: Ramona Schiumerini, Paola Baccarini, Adele Fornelli, Davide Allegri, Francesca Lodato, Alessia Gazzola, Pasquale Apolito, Nunzio P. Longo, Anna M. Polifemo, Franca Patrizi, Federica Buonfiglioli, Stefania Ghersi, Marco Bassi, Liza Ceroni, Antonella Ghetti, Giulio Fonti, Vincenzo Cennamo
Format: Article
Language:English
Published: Korean Society of Gastrointestinal Endoscopy 2025-03-01
Series:Clinical Endoscopy
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Online Access:http://e-ce.org/upload/pdf/ce-2024-113.pdf
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author Ramona Schiumerini
Paola Baccarini
Adele Fornelli
Davide Allegri
Francesca Lodato
Alessia Gazzola
Pasquale Apolito
Nunzio P. Longo
Anna M. Polifemo
Franca Patrizi
Federica Buonfiglioli
Stefania Ghersi
Marco Bassi
Liza Ceroni
Antonella Ghetti
Giulio Fonti
Vincenzo Cennamo
author_facet Ramona Schiumerini
Paola Baccarini
Adele Fornelli
Davide Allegri
Francesca Lodato
Alessia Gazzola
Pasquale Apolito
Nunzio P. Longo
Anna M. Polifemo
Franca Patrizi
Federica Buonfiglioli
Stefania Ghersi
Marco Bassi
Liza Ceroni
Antonella Ghetti
Giulio Fonti
Vincenzo Cennamo
author_sort Ramona Schiumerini
collection DOAJ
description Background/Aims Small polyps are the most frequently detected lesions during colonoscopy, with an incomplete resection rate of 6.8% to 15.9%. This study aimed to improve small polyp cold snare resection radicality using submucosal contrast dye pre-lifting (PL+CSP). Methods This single-center, prospective, randomized controlled trial compared the standard cold snare polypectomy technique (PL-CSP) with PL+CSP to evaluate endoscopic and histological complete resection rates, adverse events, procedural times, and polyp retrieval failure rates. Results: In 143 patients consecutively enrolled, 186 small polyps were detected and randomly assigned following a 1:1 ratio to the PL-CSP (n=97, 51.6%) and PL+CSP (n=90, 48.4%) techniques. Endoscopic (p=0.97) and histologic (p=0.23) complete resection rates did not differ significantly even in univariate analysis. The intraprocedural bleeding rate was significantly higher in the PL+CSP group as confirmed by the univariate analysis (35.8% vs. 8.3%, p<0.001). The polyps retrieval failure rates were similar (p=0.83). Procedural time was significantly longer for PL+CSP (median time, 75 vs. 45 seconds; p<0.001), without impacting colonoscopy withdrawal time (p=0.215). Conclusions: PL+CSP of small polyps did not improve endoscopic and histological complete resection rates and polyp sample retrieval. PL+CSP had higher rates of intraprocedural bleeding and was “time-consuming”.
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spelling doaj-art-d26b5447d0bb41b68f0f61721c9d841a2025-08-20T01:51:39ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432025-03-0158229130210.5946/ce.2024.1137948Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trialRamona Schiumerini0Paola Baccarini1Adele Fornelli2Davide Allegri3Francesca Lodato4Alessia Gazzola5Pasquale Apolito6Nunzio P. Longo7Anna M. Polifemo8Franca Patrizi9Federica Buonfiglioli10Stefania Ghersi11Marco Bassi12Liza Ceroni13Antonella Ghetti14Giulio Fonti15Vincenzo Cennamo16 Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Pathology Department, Ospedale Bellaria, Bologna, Italy Pathology Department, Ospedale Maggiore, Bologna, Italy Clinical Governance Department, Azienda Unità Sanitaria Locale (AUSL) Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, Italy Complex Gastroenterology Department, Ospedale Maggiore, Bologna, ItalyBackground/Aims Small polyps are the most frequently detected lesions during colonoscopy, with an incomplete resection rate of 6.8% to 15.9%. This study aimed to improve small polyp cold snare resection radicality using submucosal contrast dye pre-lifting (PL+CSP). Methods This single-center, prospective, randomized controlled trial compared the standard cold snare polypectomy technique (PL-CSP) with PL+CSP to evaluate endoscopic and histological complete resection rates, adverse events, procedural times, and polyp retrieval failure rates. Results: In 143 patients consecutively enrolled, 186 small polyps were detected and randomly assigned following a 1:1 ratio to the PL-CSP (n=97, 51.6%) and PL+CSP (n=90, 48.4%) techniques. Endoscopic (p=0.97) and histologic (p=0.23) complete resection rates did not differ significantly even in univariate analysis. The intraprocedural bleeding rate was significantly higher in the PL+CSP group as confirmed by the univariate analysis (35.8% vs. 8.3%, p<0.001). The polyps retrieval failure rates were similar (p=0.83). Procedural time was significantly longer for PL+CSP (median time, 75 vs. 45 seconds; p<0.001), without impacting colonoscopy withdrawal time (p=0.215). Conclusions: PL+CSP of small polyps did not improve endoscopic and histological complete resection rates and polyp sample retrieval. PL+CSP had higher rates of intraprocedural bleeding and was “time-consuming”.http://e-ce.org/upload/pdf/ce-2024-113.pdfcolonoscopydiagnostic techniquedigestive systemhistological techniques
spellingShingle Ramona Schiumerini
Paola Baccarini
Adele Fornelli
Davide Allegri
Francesca Lodato
Alessia Gazzola
Pasquale Apolito
Nunzio P. Longo
Anna M. Polifemo
Franca Patrizi
Federica Buonfiglioli
Stefania Ghersi
Marco Bassi
Liza Ceroni
Antonella Ghetti
Giulio Fonti
Vincenzo Cennamo
Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trial
Clinical Endoscopy
colonoscopy
diagnostic technique
digestive system
histological techniques
title Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trial
title_full Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trial
title_fullStr Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trial
title_full_unstemmed Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trial
title_short Impact of contrast dye submucosal pre-lifting on cold snare resection of small polyps: an Italian randomized observational trial
title_sort impact of contrast dye submucosal pre lifting on cold snare resection of small polyps an italian randomized observational trial
topic colonoscopy
diagnostic technique
digestive system
histological techniques
url http://e-ce.org/upload/pdf/ce-2024-113.pdf
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