RNA Splicing: A New Player in the DNA Damage Response
It is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations. However, the molecular basis of genomic instability in cancer is still partially understood. The observation that hereditary cancers are often characterized by mutatio...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/153634 |
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| _version_ | 1832549334687678464 |
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| author | Silvia C. Lenzken Alessia Loffreda Silvia M. L. Barabino |
| author_facet | Silvia C. Lenzken Alessia Loffreda Silvia M. L. Barabino |
| author_sort | Silvia C. Lenzken |
| collection | DOAJ |
| description | It is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations. However, the molecular basis of genomic instability in cancer is still partially understood. The observation that hereditary cancers are often characterized by mutations in DNA repair and checkpoint genes suggests that accumulation of DNA damage is a major contributor to the oncogenic transformation. It is therefore of great interest to identify all the cellular pathways that contribute to the response to DNA damage. Recently, RNA processing has emerged as a novel pathway that may contribute to the maintenance of genome stability. In this review, we illustrate several different mechanisms through which pre-mRNA splicing and genomic stability can influence each other. We specifically focus on the role of splicing factors in the DNA damage response and describe how, in turn, activation of the DDR can influence the activity of splicing factors. |
| format | Article |
| id | doaj-art-d26b52b36b6f4e80834fb32e4857c77d |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-d26b52b36b6f4e80834fb32e4857c77d2025-02-03T06:11:41ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/153634153634RNA Splicing: A New Player in the DNA Damage ResponseSilvia C. Lenzken0Alessia Loffreda1Silvia M. L. Barabino2Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, I-20126 Milan, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, I-20126 Milan, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, I-20126 Milan, ItalyIt is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations. However, the molecular basis of genomic instability in cancer is still partially understood. The observation that hereditary cancers are often characterized by mutations in DNA repair and checkpoint genes suggests that accumulation of DNA damage is a major contributor to the oncogenic transformation. It is therefore of great interest to identify all the cellular pathways that contribute to the response to DNA damage. Recently, RNA processing has emerged as a novel pathway that may contribute to the maintenance of genome stability. In this review, we illustrate several different mechanisms through which pre-mRNA splicing and genomic stability can influence each other. We specifically focus on the role of splicing factors in the DNA damage response and describe how, in turn, activation of the DDR can influence the activity of splicing factors.http://dx.doi.org/10.1155/2013/153634 |
| spellingShingle | Silvia C. Lenzken Alessia Loffreda Silvia M. L. Barabino RNA Splicing: A New Player in the DNA Damage Response International Journal of Cell Biology |
| title | RNA Splicing: A New Player in the DNA Damage Response |
| title_full | RNA Splicing: A New Player in the DNA Damage Response |
| title_fullStr | RNA Splicing: A New Player in the DNA Damage Response |
| title_full_unstemmed | RNA Splicing: A New Player in the DNA Damage Response |
| title_short | RNA Splicing: A New Player in the DNA Damage Response |
| title_sort | rna splicing a new player in the dna damage response |
| url | http://dx.doi.org/10.1155/2013/153634 |
| work_keys_str_mv | AT silviaclenzken rnasplicinganewplayerinthednadamageresponse AT alessialoffreda rnasplicinganewplayerinthednadamageresponse AT silviamlbarabino rnasplicinganewplayerinthednadamageresponse |