Adipose-derived stem cells extracellular vesicles enhance diabetic wound healing via CCN2/PI3K/AKT pathway: therapeutic potential and mechanistic insights

Adipose-derived stem cells extracellular vesicles enhance diabetic wound healing via CCN2/PI3K/AKT pathway: therapeutic potential and mechanistic insights

Abstract Background Adipose-derived stem cells extracellular vesicles (ADSCs-EVs) hold significant promise in tissue repair and regeneration. While they have been reported to enhance diabetic wound healing, the precise mechanisms remain unclear. Methods ADSCs-EVs were isolated via ultracentrifugatio...

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Bibliographic Details
Main Authors:	Yu-lu Zhou, Shingo Ogura, Hao Ma, Rong-bin Liang, Shao-yihan Fang, Yue-ming Wang, Yan Wo, Wen-jin Wang, De-Wu Liu
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Series:	Stem Cell Research & Therapy
Subjects:	Adipose-derived stem cells extracellular vesicles (ADSCs-EVs) Diabetic wound healing Angiogenesis Cellular communication network factor 2 (CCN2) PI3K/AKT signaling pathway
Online Access:	https://doi.org/10.1186/s13287-025-04354-x
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