Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS
Abstract Background The triacylglycerol to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been recognized as one of the risk factors for cardiovascular diseases, insulin resistance and metabolic syndrome. We aimed to investigate the relationship between TG/HDL-C and hypertension in a Chin...
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BMC
2025-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04712-w |
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| author | Lerui Wang Xiao Chen Weicheng Lai Junxi Liu Boda Zhou |
| author_facet | Lerui Wang Xiao Chen Weicheng Lai Junxi Liu Boda Zhou |
| author_sort | Lerui Wang |
| collection | DOAJ |
| description | Abstract Background The triacylglycerol to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been recognized as one of the risk factors for cardiovascular diseases, insulin resistance and metabolic syndrome. We aimed to investigate the relationship between TG/HDL-C and hypertension in a Chinese middle-aged and elderly population. Methods We used data from the CHARLS database 2011–2018 to explore the relationship between TG/HDL-C and hypertension through cross-sectional and longitudinal studies. Hypertension was identified by self-report or taking anti-hypertensive medications. Participants aged below 45, or with missing data on TG/HDL-C or hypertension record, or taking lipid-lowering medication were excluded. Participants were divided into three or two groups based on triplets TG/HDL-C and median TG/HDL-C in cross-sectional and longitudinal analysis. Multivariate logistic regression analysis, subgroup analysis, and restricted cubic splines were used in statistics. Results In the cross-sectional analysis, a total of 12,824 participants were included, after adjusting for potential confounders, there was a significant association between higher TG/HDL-C and increased prevalence of hypertension (OR = 1.86, 95% CI: 1.65–2.09, p < 0.001), systolic blood pressure (SBP) above 140 mmHg (OR = 1.37, 95% CI: 1.25–1.50, p < 0.0001), diastolic blood pressure (DBP) above 90 mmHg (OR = 1.47, 95% CI: 1.29–1.67, p < 0.0001), and pulse pressure (PP) above 60 mmHg (OR = 1.17, 95% CI: 1.07–1.29, p < 0.0011). The longitudinal analysis included 7909 participants, there was a significant association between higher TG/HDL-C and increased incidence of hypertension (OR = 1.51, 95% CI: 1.32–1.73,p < 0.001). Restricted cubic splines show nonlinear relationship between TG/HDL-C and hypertension. Conclusion These results demonstrated significant positive association between TG/HDL-C and the prevalence & incidence of hypertension, in a nationwide representative middle-aged and elderly population in China. |
| format | Article |
| id | doaj-art-d26810ec30b841869e6ee5b3d41f8099 |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-d26810ec30b841869e6ee5b3d41f80992025-08-20T03:08:02ZengBMCBMC Cardiovascular Disorders1471-22612025-04-0125111010.1186/s12872-025-04712-wAssociation between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLSLerui Wang0Xiao Chen1Weicheng Lai2Junxi Liu3Boda Zhou4Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua UniversityDepartment of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua UniversityDepartment of Cardiology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical UniversitySchool of Life Science, Tsinghua UniversityDepartment of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua UniversityAbstract Background The triacylglycerol to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been recognized as one of the risk factors for cardiovascular diseases, insulin resistance and metabolic syndrome. We aimed to investigate the relationship between TG/HDL-C and hypertension in a Chinese middle-aged and elderly population. Methods We used data from the CHARLS database 2011–2018 to explore the relationship between TG/HDL-C and hypertension through cross-sectional and longitudinal studies. Hypertension was identified by self-report or taking anti-hypertensive medications. Participants aged below 45, or with missing data on TG/HDL-C or hypertension record, or taking lipid-lowering medication were excluded. Participants were divided into three or two groups based on triplets TG/HDL-C and median TG/HDL-C in cross-sectional and longitudinal analysis. Multivariate logistic regression analysis, subgroup analysis, and restricted cubic splines were used in statistics. Results In the cross-sectional analysis, a total of 12,824 participants were included, after adjusting for potential confounders, there was a significant association between higher TG/HDL-C and increased prevalence of hypertension (OR = 1.86, 95% CI: 1.65–2.09, p < 0.001), systolic blood pressure (SBP) above 140 mmHg (OR = 1.37, 95% CI: 1.25–1.50, p < 0.0001), diastolic blood pressure (DBP) above 90 mmHg (OR = 1.47, 95% CI: 1.29–1.67, p < 0.0001), and pulse pressure (PP) above 60 mmHg (OR = 1.17, 95% CI: 1.07–1.29, p < 0.0011). The longitudinal analysis included 7909 participants, there was a significant association between higher TG/HDL-C and increased incidence of hypertension (OR = 1.51, 95% CI: 1.32–1.73,p < 0.001). Restricted cubic splines show nonlinear relationship between TG/HDL-C and hypertension. Conclusion These results demonstrated significant positive association between TG/HDL-C and the prevalence & incidence of hypertension, in a nationwide representative middle-aged and elderly population in China.https://doi.org/10.1186/s12872-025-04712-wCHARLSHypertensionTG/HDL-CNonlinearElderly |
| spellingShingle | Lerui Wang Xiao Chen Weicheng Lai Junxi Liu Boda Zhou Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS BMC Cardiovascular Disorders CHARLS Hypertension TG/HDL-C Nonlinear Elderly |
| title | Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS |
| title_full | Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS |
| title_fullStr | Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS |
| title_full_unstemmed | Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS |
| title_short | Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS |
| title_sort | association between tg hdl c and hypertension in chinese middle aged and older adults findings from charls |
| topic | CHARLS Hypertension TG/HDL-C Nonlinear Elderly |
| url | https://doi.org/10.1186/s12872-025-04712-w |
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