Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle
Gene expression involves a series of consequential processes, beginning with mRNA synthesis and culminating in translation. Traditionally studied as a linear sequence of events, recent findings challenge this perspective, revealing coupling mechanisms that coordinate key steps of gene expression, ev...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | RNA Biology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2025.2483001 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850099076521000960 |
|---|---|
| author | Valeria Famà Lucia Coscujuela Tarrero Roberto Albanese Lorenzo Calviello Stefano Biffo Mattia Pelizzola Mattia Furlan |
| author_facet | Valeria Famà Lucia Coscujuela Tarrero Roberto Albanese Lorenzo Calviello Stefano Biffo Mattia Pelizzola Mattia Furlan |
| author_sort | Valeria Famà |
| collection | DOAJ |
| description | Gene expression involves a series of consequential processes, beginning with mRNA synthesis and culminating in translation. Traditionally studied as a linear sequence of events, recent findings challenge this perspective, revealing coupling mechanisms that coordinate key steps of gene expression, even when spatially and temporally distant. In this review, we focus on translation, the final stage of gene expression, and examine its coupling with key stages of mRNA metabolism: synthesis, processing, export, and decay. For each of these processes, we provide an overview of known instances of coupling with translation. Furthermore, we discuss the role of high-throughput technologies in uncovering these intricate interactions on a genome-wide scale. Finally, we highlight key challenges and propose future directions to advance our understanding of how coupling mechanisms orchestrate robust and adaptable gene expression programs. |
| format | Article |
| id | doaj-art-d26126eef47b4d45ba34bd9004c01aac |
| institution | DOAJ |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-d26126eef47b4d45ba34bd9004c01aac2025-08-20T02:40:33ZengTaylor & Francis GroupRNA Biology1547-62861555-85842025-12-0122111210.1080/15476286.2025.2483001Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycleValeria Famà0Lucia Coscujuela Tarrero1Roberto Albanese2Lorenzo Calviello3Stefano Biffo4Mattia Pelizzola5Mattia Furlan6Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan, ItalyCenter for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan, ItalyHuman Technopole, Milan, ItalyHuman Technopole, Milan, ItalyNational Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, INGM, Milan, ItalyCenter for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan, ItalyCenter for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan, ItalyGene expression involves a series of consequential processes, beginning with mRNA synthesis and culminating in translation. Traditionally studied as a linear sequence of events, recent findings challenge this perspective, revealing coupling mechanisms that coordinate key steps of gene expression, even when spatially and temporally distant. In this review, we focus on translation, the final stage of gene expression, and examine its coupling with key stages of mRNA metabolism: synthesis, processing, export, and decay. For each of these processes, we provide an overview of known instances of coupling with translation. Furthermore, we discuss the role of high-throughput technologies in uncovering these intricate interactions on a genome-wide scale. Finally, we highlight key challenges and propose future directions to advance our understanding of how coupling mechanisms orchestrate robust and adaptable gene expression programs.https://www.tandfonline.com/doi/10.1080/15476286.2025.2483001Translationtranscriptionprocessingexportdecaycoupling |
| spellingShingle | Valeria Famà Lucia Coscujuela Tarrero Roberto Albanese Lorenzo Calviello Stefano Biffo Mattia Pelizzola Mattia Furlan Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle RNA Biology Translation transcription processing export decay coupling |
| title | Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle |
| title_full | Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle |
| title_fullStr | Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle |
| title_full_unstemmed | Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle |
| title_short | Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle |
| title_sort | coupling mechanisms coordinating mrna translation with stages of the mrna lifecycle |
| topic | Translation transcription processing export decay coupling |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2025.2483001 |
| work_keys_str_mv | AT valeriafama couplingmechanismscoordinatingmrnatranslationwithstagesofthemrnalifecycle AT luciacoscujuelatarrero couplingmechanismscoordinatingmrnatranslationwithstagesofthemrnalifecycle AT robertoalbanese couplingmechanismscoordinatingmrnatranslationwithstagesofthemrnalifecycle AT lorenzocalviello couplingmechanismscoordinatingmrnatranslationwithstagesofthemrnalifecycle AT stefanobiffo couplingmechanismscoordinatingmrnatranslationwithstagesofthemrnalifecycle AT mattiapelizzola couplingmechanismscoordinatingmrnatranslationwithstagesofthemrnalifecycle AT mattiafurlan couplingmechanismscoordinatingmrnatranslationwithstagesofthemrnalifecycle |