Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional Study
Huan Dong,1,2,* Ye Liu,1,2,* Xianjing Wang,1,2 Ping Liu1,2 1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, People’s R...
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Dove Medical Press
2025-04-01
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| author | Dong H Liu Y Wang X Liu P |
| author_facet | Dong H Liu Y Wang X Liu P |
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| description | Huan Dong,1,2,* Ye Liu,1,2,* Xianjing Wang,1,2 Ping Liu1,2 1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ping Liu; Xianjing Wang, Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Road, Shanghai, 200030, People’s Republic of China, Email lping1016@163.com; 18017310156@163.comPurpose: The fat-to-muscle mass ratio (FMR) is a novel anthropometric parameter that integrates the antagonistic effects of fat and muscle mass. The current study aimed to examine the associations between total and region-specific FMR with the prevalence of self-reported infertility in US women.Methods: US women aged 20 to 44 years from the 2013– 2018 National Health and Nutrition Examination Survey were included. Total, trunk, arm, and leg FMR were calculated from fat mass and muscle mass in the corresponding body part by dual-energy X-ray absorptiometry. Binary logistic regression, restricted cubic spline analysis and subgroup analysis were primarily used for statistical analyses.Results: Infertility prevalence was 12.77% among the 1958 women included. Arm and leg FMR were not associated with infertility prevalence, while the odds ratio and 95% confidence intervals for infertility by each 0.1 point increase in trunk and total FMR were 1.19 (1.07– 1.33) and 1.16 (1.04– 1.30), respectively. Restricted cubic spline analysis indicated a positive and linear relationship between trunk or total FMR and infertility prevalence. Subgroup analysis consistently demonstrated that the associations between trunk or total FMR with infertility prevalence were more pronounced in women without a pregnancy history than in those with a pregnancy history. The receiver-operating characteristic curves indicated that the trunk FMR outperformed total, arm, and leg FMR in discriminating infertility from women without infertility.Conclusion: Trunk and total FMR, rather than arm or leg FMR, were associated with an increased risk of infertility in US women, especially those without a prior pregnancy history.Keywords: cross-sectional, dual-energy X-ray absorptiometry, fat-to-muscle mass ratio, infertility, NHANES |
| format | Article |
| id | doaj-art-d25bb187da0546f9b4aac3feff3434a5 |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-d25bb187da0546f9b4aac3feff3434a52025-08-20T01:47:55ZengDove Medical PressJournal of Multidisciplinary Healthcare1178-23902025-04-01Volume 1821732184102154Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional StudyDong HLiu YWang XLiu PHuan Dong,1,2,* Ye Liu,1,2,* Xianjing Wang,1,2 Ping Liu1,2 1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ping Liu; Xianjing Wang, Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Road, Shanghai, 200030, People’s Republic of China, Email lping1016@163.com; 18017310156@163.comPurpose: The fat-to-muscle mass ratio (FMR) is a novel anthropometric parameter that integrates the antagonistic effects of fat and muscle mass. The current study aimed to examine the associations between total and region-specific FMR with the prevalence of self-reported infertility in US women.Methods: US women aged 20 to 44 years from the 2013– 2018 National Health and Nutrition Examination Survey were included. Total, trunk, arm, and leg FMR were calculated from fat mass and muscle mass in the corresponding body part by dual-energy X-ray absorptiometry. Binary logistic regression, restricted cubic spline analysis and subgroup analysis were primarily used for statistical analyses.Results: Infertility prevalence was 12.77% among the 1958 women included. Arm and leg FMR were not associated with infertility prevalence, while the odds ratio and 95% confidence intervals for infertility by each 0.1 point increase in trunk and total FMR were 1.19 (1.07– 1.33) and 1.16 (1.04– 1.30), respectively. Restricted cubic spline analysis indicated a positive and linear relationship between trunk or total FMR and infertility prevalence. Subgroup analysis consistently demonstrated that the associations between trunk or total FMR with infertility prevalence were more pronounced in women without a pregnancy history than in those with a pregnancy history. The receiver-operating characteristic curves indicated that the trunk FMR outperformed total, arm, and leg FMR in discriminating infertility from women without infertility.Conclusion: Trunk and total FMR, rather than arm or leg FMR, were associated with an increased risk of infertility in US women, especially those without a prior pregnancy history.Keywords: cross-sectional, dual-energy X-ray absorptiometry, fat-to-muscle mass ratio, infertility, NHANEShttps://www.dovepress.com/associations-between-total-and-regional-fat-to-muscle-mass-ratio-with--peer-reviewed-fulltext-article-JMDHcross-sectionaldual-energy x-ray absorptiometryfat-to-muscle mass ratioinfertilitynhanes |
| spellingShingle | Dong H Liu Y Wang X Liu P Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional Study Journal of Multidisciplinary Healthcare cross-sectional dual-energy x-ray absorptiometry fat-to-muscle mass ratio infertility nhanes |
| title | Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional Study |
| title_full | Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional Study |
| title_fullStr | Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional Study |
| title_full_unstemmed | Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional Study |
| title_short | Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional Study |
| title_sort | associations between total and regional fat to muscle mass ratio with the prevalence of infertility a cross sectional study |
| topic | cross-sectional dual-energy x-ray absorptiometry fat-to-muscle mass ratio infertility nhanes |
| url | https://www.dovepress.com/associations-between-total-and-regional-fat-to-muscle-mass-ratio-with--peer-reviewed-fulltext-article-JMDH |
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