Risk Factors and Diagnosis of Head and Neck Squamous Cell Carcinoma
Head and Neck Squamous Cell Carcinoma (HNSCC) ranks among the seven most prevalent malignancies globally, associated with significant morbidity and mortality rates. The key risk factors for this malignancy include chronic alcohol consumption, tobacco use, immunosuppression, and infections with oncog...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Padjajaran
2024-12-01
|
| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3729 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849707605120778240 |
|---|---|
| author | Yussy Afriani Dewi Ifiq Nazar Anis Farida |
| author_facet | Yussy Afriani Dewi Ifiq Nazar Anis Farida |
| author_sort | Yussy Afriani Dewi |
| collection | DOAJ |
| description | Head and Neck Squamous Cell Carcinoma (HNSCC) ranks among the seven most prevalent malignancies globally, associated with significant morbidity and mortality rates. The key risk factors for this malignancy include chronic alcohol consumption, tobacco use, immunosuppression, and infections with oncogenic viruses such as high-risk Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV). This study was a retrospective analysis of HNSCC patients seen at an oncology clinic over a five-year period from January 2015 to December 2020, focusing on the environmental and genetic factors contributing to the disease. A cohort of 1,640 patients was analyzed, assessing their risk factors and diagnostic outcomes. Results indicated that smoking and alcohol consumption were the most significant independent risk factors, displaying a synergistic effect in disease progression. Other variables explored were exposure to air pollution, HPV and EBV infections, age, dietary deficiencies in vegetables, and genetic predispositions. While some factors were statistically significant, others showed weaker associations. This study highlights the importance of preventive strategies focusing on modifiable risk factors, such as lifestyle changes and viral vaccination, to reduce the incidence of HNSCC. |
| format | Article |
| id | doaj-art-d25aad7a88da4b1cad1546921ef0faae |
| institution | DOAJ |
| issn | 0126-074X 2338-6223 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj-art-d25aad7a88da4b1cad1546921ef0faae2025-08-20T03:15:53ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232024-12-0156427828410.15395/mkb.v56.37291789Risk Factors and Diagnosis of Head and Neck Squamous Cell CarcinomaYussy Afriani Dewi0Ifiq Nazar1Anis Farida2Department of Otorhinolaryngology-Head and Neck Surgery Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungDepartment of Otorhinolaryngology-Head and Neck Surgery Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungDepartment of Otorhinolaryngology-Head and Neck Surgery Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungHead and Neck Squamous Cell Carcinoma (HNSCC) ranks among the seven most prevalent malignancies globally, associated with significant morbidity and mortality rates. The key risk factors for this malignancy include chronic alcohol consumption, tobacco use, immunosuppression, and infections with oncogenic viruses such as high-risk Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV). This study was a retrospective analysis of HNSCC patients seen at an oncology clinic over a five-year period from January 2015 to December 2020, focusing on the environmental and genetic factors contributing to the disease. A cohort of 1,640 patients was analyzed, assessing their risk factors and diagnostic outcomes. Results indicated that smoking and alcohol consumption were the most significant independent risk factors, displaying a synergistic effect in disease progression. Other variables explored were exposure to air pollution, HPV and EBV infections, age, dietary deficiencies in vegetables, and genetic predispositions. While some factors were statistically significant, others showed weaker associations. This study highlights the importance of preventive strategies focusing on modifiable risk factors, such as lifestyle changes and viral vaccination, to reduce the incidence of HNSCC.https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3729alcohol, carcinoma, diagnosis, head and neck cancer |
| spellingShingle | Yussy Afriani Dewi Ifiq Nazar Anis Farida Risk Factors and Diagnosis of Head and Neck Squamous Cell Carcinoma Majalah Kedokteran Bandung alcohol, carcinoma, diagnosis, head and neck cancer |
| title | Risk Factors and Diagnosis of Head and Neck Squamous Cell Carcinoma |
| title_full | Risk Factors and Diagnosis of Head and Neck Squamous Cell Carcinoma |
| title_fullStr | Risk Factors and Diagnosis of Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | Risk Factors and Diagnosis of Head and Neck Squamous Cell Carcinoma |
| title_short | Risk Factors and Diagnosis of Head and Neck Squamous Cell Carcinoma |
| title_sort | risk factors and diagnosis of head and neck squamous cell carcinoma |
| topic | alcohol, carcinoma, diagnosis, head and neck cancer |
| url | https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3729 |
| work_keys_str_mv | AT yussyafrianidewi riskfactorsanddiagnosisofheadandnecksquamouscellcarcinoma AT ifiqnazar riskfactorsanddiagnosisofheadandnecksquamouscellcarcinoma AT anisfarida riskfactorsanddiagnosisofheadandnecksquamouscellcarcinoma |