Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, affecting approximately 30% of the adult population. Growing evidence supports the developmental origins of liver diseases, with early-life exposure to environmental chemicals emerg...
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| Format: | Article |
| Language: | zho |
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Lanzhou University Press
2025-03-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20250102 |
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| author | Zhang Hongchao Francisco Javier Cubero Zhao Gang Xu Jin Liu Qian Shao Wentao Gu Aihua |
| author_facet | Zhang Hongchao Francisco Javier Cubero Zhao Gang Xu Jin Liu Qian Shao Wentao Gu Aihua |
| author_sort | Zhang Hongchao |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, affecting approximately 30% of the adult population. Growing evidence supports the developmental origins of liver diseases, with early-life exposure to environmental chemicals emerging as a critical risk factor for MASLD in adulthood. Early-life exposure to environmental chemicals may exert a "programming effect" on hepatic development and metabolic function by disrupting nuclear receptor signaling, impairing mitochondrial homeostasis, inducing epigenetic reprogramming, and mediating liver-extrahepatic organ crosstalk, thereby significantly increasing the risk of MASLD in adulthood. Furthermore, paternal exposure has been shown to affect offspring hepatic metabolism through transgenerational epigenetic mechanisms. From the perspective of the Developmental Origins of Health and Disease (DOHaD) theory, this review summarizes environmental risk factors that impair hepatic metabolic function in adulthood and their underlying mechanisms. |
| format | Article |
| id | doaj-art-d253b73685164db9b9c6a2463369168a |
| institution | DOAJ |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-d253b73685164db9b9c6a2463369168a2025-08-20T03:04:20ZzhoLanzhou University Press生物医学转化2096-89652025-03-016129,1910.12287/j.issn.2096-8965.20250101Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspectiveZhang Hongchao0Francisco Javier Cubero1Zhao Gang2Xu Jin3Liu Qian4Shao Wentao5Gu Aihua6 Center of Gallstone Disease, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120 , China ; Institute of Gallstone Disease, School of Medicine, Tongji University, Shanghai 200120 , ChinaSchool of Medicine, Complutense University, Madrid 28040, SpainCenter of Gallstone Disease, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120 , China; Institute of Gallstone Disease, School of Medicine, Tongji University, Shanghai 200120 , ChinaSchool of Public Health, Nanjing Medical University, Jiangsu Engineering Research Center for Environmental Health Risk Assessment, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing 211166 , Jiangsu, China School of Public Health, Nanjing Medical University, Jiangsu Engineering Research Center for Environmental Health Risk Assessment, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing 211166 , Jiangsu, ChinaCenter of Gallstone Disease, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120 , China ; Institute of Gallstone Disease, School of Medicine, Tongji University, Shanghai 200120 , China ; School of Public Health, Nanjing Medical University, Jiangsu Engineering Research Center for Environmental Health Risk Assessment, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing 211166 , Jiangsu, ChinaSchool of Public Health, Nanjing Medical University, Jiangsu Engineering Research Center for Environmental Health Risk Assessment, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing 211166 , Jiangsu, ChinaMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, affecting approximately 30% of the adult population. Growing evidence supports the developmental origins of liver diseases, with early-life exposure to environmental chemicals emerging as a critical risk factor for MASLD in adulthood. Early-life exposure to environmental chemicals may exert a "programming effect" on hepatic development and metabolic function by disrupting nuclear receptor signaling, impairing mitochondrial homeostasis, inducing epigenetic reprogramming, and mediating liver-extrahepatic organ crosstalk, thereby significantly increasing the risk of MASLD in adulthood. Furthermore, paternal exposure has been shown to affect offspring hepatic metabolism through transgenerational epigenetic mechanisms. From the perspective of the Developmental Origins of Health and Disease (DOHaD) theory, this review summarizes environmental risk factors that impair hepatic metabolic function in adulthood and their underlying mechanisms.http://swyxzh.ijournals.cn/swyxzh/article/html/20250102metabolic dysfunction-associated steatotic liver diseasetoxicant-associated fatty liver diseaseearly-life exposureenvironmental pollutantdevelopmental toxicitymetabolic syndrometransgenerational effectepigenetic mechanism |
| spellingShingle | Zhang Hongchao Francisco Javier Cubero Zhao Gang Xu Jin Liu Qian Shao Wentao Gu Aihua Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective 生物医学转化 metabolic dysfunction-associated steatotic liver disease toxicant-associated fatty liver disease early-life exposure environmental pollutant developmental toxicity metabolic syndrome transgenerational effect epigenetic mechanism |
| title | Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective |
| title_full | Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective |
| title_fullStr | Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective |
| title_full_unstemmed | Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective |
| title_short | Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective |
| title_sort | effect of early life exposure to environmental risk factors on adult masld insights from dohad perspective |
| topic | metabolic dysfunction-associated steatotic liver disease toxicant-associated fatty liver disease early-life exposure environmental pollutant developmental toxicity metabolic syndrome transgenerational effect epigenetic mechanism |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20250102 |
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