Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury

Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury

Abstract Mitochondrial dysfunction is a crucial event in acute kidney injury (AKI), leading to a metabolic shift toward glycolysis and increased lactate production. Lactylation, a posttranslational modification derived from lactate, plays a significant role in various cellular processes, yet its imp...

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Bibliographic Details
Main Authors: Jiaying Li, Xiaoxiao Shi, Jiatong Xu, Kaiyue Wang, Fangxing Hou, Xiaodong Luan, Limeng Chen
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
acute kidney injury
ALHD2
lactylation
mitochondrial function
mitophagy
Online Access:https://doi.org/10.1002/advs.202411943
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