Acquired Thrombotic Thrombocytopenic Purpura After ChAdOx1 nCoV-19 Vaccine: A Case Report
COVID-19, the illness caused by SARS-CoV-2, continues to cause significant morbidity and mortality across the world. An important step in overcoming SARS-CoV-2 is the global vaccination plan. Cases of acquired thrombotic thrombocytopenic purpura (aTTP) have been recently described after SARS-CoV-2 v...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2022-07-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2021.0110 |
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| author | Domenica Caramazza Marco Salvini Vincenzo Saturni Francesco Ripamonti Michele Merli Benedetta Bianchi Stefania Agnoli Davide Sirocchi Barbara Mora Elena Galfrascoli Francesco Passamonti |
| author_facet | Domenica Caramazza Marco Salvini Vincenzo Saturni Francesco Ripamonti Michele Merli Benedetta Bianchi Stefania Agnoli Davide Sirocchi Barbara Mora Elena Galfrascoli Francesco Passamonti |
| author_sort | Domenica Caramazza |
| collection | DOAJ |
| description | COVID-19, the illness caused by SARS-CoV-2, continues to cause significant morbidity and mortality across the world. An important step in overcoming SARS-CoV-2 is the global vaccination plan. Cases of acquired thrombotic thrombocytopenic purpura (aTTP) have been recently described after SARS-CoV-2 vaccination. We describe a patient case of aTTP occurring 25 days after ChAdOx1 nCov-19 (Vaxzervria/AstraZeneca) vaccination that was promptly treated with plasma exchange, corticosteroids, rituximab, and caplacizumab. Remission of aTTP was achieved in 2 weeks and the patient is currently in complete remission. |
| format | Article |
| id | doaj-art-d2489e4a14f54024b8581f7db6fff69f |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-d2489e4a14f54024b8581f7db6fff69f2025-08-20T02:12:58ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642022-07-011510.7326/aimcc.2021.0110Acquired Thrombotic Thrombocytopenic Purpura After ChAdOx1 nCoV-19 Vaccine: A Case ReportDomenica Caramazza0Marco Salvini1Vincenzo Saturni2Francesco Ripamonti3Michele Merli4Benedetta Bianchi5Stefania Agnoli6Davide Sirocchi7Barbara Mora8Elena Galfrascoli9Francesco Passamonti101Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy1Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy2Transfusion Service, University Hospital Ospedale di Circolo e Fondazione Macchi, ASST Sette Laghi, Varese, Italy1Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy1Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy1Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy1Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy1Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy1Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy3Hospital Pharmacy, Ospedale di Circolo e Fondazione Macchi, ASST Sette Laghi, Varese, Italy1Hematology, University Hospital ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, ItalyCOVID-19, the illness caused by SARS-CoV-2, continues to cause significant morbidity and mortality across the world. An important step in overcoming SARS-CoV-2 is the global vaccination plan. Cases of acquired thrombotic thrombocytopenic purpura (aTTP) have been recently described after SARS-CoV-2 vaccination. We describe a patient case of aTTP occurring 25 days after ChAdOx1 nCov-19 (Vaxzervria/AstraZeneca) vaccination that was promptly treated with plasma exchange, corticosteroids, rituximab, and caplacizumab. Remission of aTTP was achieved in 2 weeks and the patient is currently in complete remission.https://www.acpjournals.org/doi/10.7326/aimcc.2021.0110 |
| spellingShingle | Domenica Caramazza Marco Salvini Vincenzo Saturni Francesco Ripamonti Michele Merli Benedetta Bianchi Stefania Agnoli Davide Sirocchi Barbara Mora Elena Galfrascoli Francesco Passamonti Acquired Thrombotic Thrombocytopenic Purpura After ChAdOx1 nCoV-19 Vaccine: A Case Report Annals of Internal Medicine: Clinical Cases |
| title | Acquired Thrombotic Thrombocytopenic Purpura After ChAdOx1 nCoV-19 Vaccine: A Case Report |
| title_full | Acquired Thrombotic Thrombocytopenic Purpura After ChAdOx1 nCoV-19 Vaccine: A Case Report |
| title_fullStr | Acquired Thrombotic Thrombocytopenic Purpura After ChAdOx1 nCoV-19 Vaccine: A Case Report |
| title_full_unstemmed | Acquired Thrombotic Thrombocytopenic Purpura After ChAdOx1 nCoV-19 Vaccine: A Case Report |
| title_short | Acquired Thrombotic Thrombocytopenic Purpura After ChAdOx1 nCoV-19 Vaccine: A Case Report |
| title_sort | acquired thrombotic thrombocytopenic purpura after chadox1 ncov 19 vaccine a case report |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2021.0110 |
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