Macrophage-Specific Progranulin Deficiency Prevents Diet-Induced Obesity through the Inhibition of Hypothalamic and Adipose Tissue Inflammation

Macrophage-Specific Progranulin Deficiency Prevents Diet-Induced Obesity through the Inhibition of Hypothalamic and Adipose Tissue Inflammation

Background Chronic low-grade inflammation in multiple metabolic organs contributes to the development of insulin resistance induced by obesity. Progranulin (PGRN) is an evolutionarily-conserved secretory protein implicated in immune modulation. The generalized deletion of the PGRN-encoded Grn gene i...

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Bibliographic Details
Main Authors: Chan Hee Lee, Chae Beom Park, Hyun-Kyong Kim, Won Hee Jang, Se Hee Min, Jae Bum Kim, Min-Seon Kim
Format: Article
Language:English
Published: Korean Diabetes Association 2025-07-01
Series:Diabetes & Metabolism Journal
Subjects:
adipose tissue
hypothalamus
inflammation
macrophages
metabolic diseases
obesity
progranulins
Online Access:http://e-dmj.org/upload/pdf/dmj-2024-0486.pdf
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