Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience
Tuberculosis is a significant cause of morbidity worldwide and is a priority at the provincial and federal levels in Canada. It is known that tuberculosis transmission networks are complex and span many years as well as different jurisdictions and countries. MIRU-VNTR is a universal tuberculosis gen...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2022/3505142 |
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| author | Meenu K. Sharma Debra Janella Alisa McGurran Cindi Corbett Heather Adam Pierre-Marie Akochy David Haldane Hope MacKenzie Jessica Minion Robert Needle Caroline Newberry Michael Patterson Inna Sekirov Gregory Tyrrell Hafid Soualhine |
| author_facet | Meenu K. Sharma Debra Janella Alisa McGurran Cindi Corbett Heather Adam Pierre-Marie Akochy David Haldane Hope MacKenzie Jessica Minion Robert Needle Caroline Newberry Michael Patterson Inna Sekirov Gregory Tyrrell Hafid Soualhine |
| author_sort | Meenu K. Sharma |
| collection | DOAJ |
| description | Tuberculosis is a significant cause of morbidity worldwide and is a priority at the provincial and federal levels in Canada. It is known that tuberculosis transmission networks are complex and span many years as well as different jurisdictions and countries. MIRU-VNTR is a universal tuberculosis genotyping method that utilizes a 24-loci pattern and it has shown promise in identifying inter and intrajurisdictional clusters within Canada. MIRU-VNTR data collected over 10 years from the National Reference Centre for Mycobacteriology (NRCM) were analyzed in this study. Some clusters were unique to a single province/territory, while others spanned multiple provinces and/or territories in Canada. The use of a universal laboratory test can enhance contact tracing, provide geographical information on circulating genotypes, and hence, aid in tuberculosis investigation by public health. The housing of all data on one platform, technical ease of the method, easy exchange of data between jurisdictions, and strong collaboration with laboratories and surveillance units at the provincial and federal levels have the potential to identify possible outbreaks in real time. |
| format | Article |
| id | doaj-art-d24353c536114d96ad5a294c6d0e1412 |
| institution | Kabale University |
| issn | 1918-1493 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-d24353c536114d96ad5a294c6d0e14122025-02-03T01:21:06ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932022-01-01202210.1155/2022/3505142Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s ExperienceMeenu K. Sharma0Debra Janella1Alisa McGurran2Cindi Corbett3Heather Adam4Pierre-Marie Akochy5David Haldane6Hope MacKenzie7Jessica Minion8Robert Needle9Caroline Newberry10Michael Patterson11Inna Sekirov12Gregory Tyrrell13Hafid Soualhine14National Reference Centre for MycobacteriologyNational Reference Centre for MycobacteriologyNational Reference Centre for MycobacteriologyNational Reference Centre for MycobacteriologyShared HealthLaboratoire de Sante Publique du QuebecPublic Health Laboratory NetworkAtlantic Health Sciences CorporationSaskatchewan Health AuthorityNewfoundland and Labrador Public Health LaboratoryOffice of Chief Public Health OfficerGovernment of NunavutBC Centre for Disease ControlAlberta Health ServicesNational Reference Centre for MycobacteriologyTuberculosis is a significant cause of morbidity worldwide and is a priority at the provincial and federal levels in Canada. It is known that tuberculosis transmission networks are complex and span many years as well as different jurisdictions and countries. MIRU-VNTR is a universal tuberculosis genotyping method that utilizes a 24-loci pattern and it has shown promise in identifying inter and intrajurisdictional clusters within Canada. MIRU-VNTR data collected over 10 years from the National Reference Centre for Mycobacteriology (NRCM) were analyzed in this study. Some clusters were unique to a single province/territory, while others spanned multiple provinces and/or territories in Canada. The use of a universal laboratory test can enhance contact tracing, provide geographical information on circulating genotypes, and hence, aid in tuberculosis investigation by public health. The housing of all data on one platform, technical ease of the method, easy exchange of data between jurisdictions, and strong collaboration with laboratories and surveillance units at the provincial and federal levels have the potential to identify possible outbreaks in real time.http://dx.doi.org/10.1155/2022/3505142 |
| spellingShingle | Meenu K. Sharma Debra Janella Alisa McGurran Cindi Corbett Heather Adam Pierre-Marie Akochy David Haldane Hope MacKenzie Jessica Minion Robert Needle Caroline Newberry Michael Patterson Inna Sekirov Gregory Tyrrell Hafid Soualhine Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience |
| title_full | Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience |
| title_fullStr | Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience |
| title_full_unstemmed | Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience |
| title_short | Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience |
| title_sort | compilation of 10 years of miru vntr data canadian national tuberculosis laboratory s experience |
| url | http://dx.doi.org/10.1155/2022/3505142 |
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