Comparative analysis of brivaracetam and levetiracetam in epilepsy treatment
Epilepsy affects millions of people worldwide, necessitating effective and safe treatment options. Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that target the synaptic vesicle protein 2A (SV2A). Despite the similarities in their chemical structure, BRV and LEV exhibit distinct...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Tungs’ Medical Journal |
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| Online Access: | https://doi.org/10.4103/ETMJ.ETMJ-D-24-00027 |
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| author | Ming-Yuan Hsu Shu-Wei Hu Hueng-Chuen Fan |
| author_facet | Ming-Yuan Hsu Shu-Wei Hu Hueng-Chuen Fan |
| author_sort | Ming-Yuan Hsu |
| collection | DOAJ |
| description | Epilepsy affects millions of people worldwide, necessitating effective and safe treatment options. Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that target the synaptic vesicle protein 2A (SV2A). Despite the similarities in their chemical structure, BRV and LEV exhibit distinct pharmacological profiles. This study provides a detailed comparative analysis of BRV and LEV, focusing on their mechanisms of action, preclinical profiles, and pharmacokinetic and pharmacodynamic properties. Clinical trial data highlight the efficacy and safety of both drugs, with BRV showing a higher affinity for SV2A and greater potency in certain seizure models. Additionally, emerging treatment strategies and future directions in epilepsy research are discussed, highlighting the potential for BRV and LEV in advancing epilepsy care. |
| format | Article |
| id | doaj-art-d23ca1090b5b4807bd30d6ebc61bab15 |
| institution | Kabale University |
| issn | 2071-3592 2949-9720 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tungs’ Medical Journal |
| spelling | doaj-art-d23ca1090b5b4807bd30d6ebc61bab152025-08-20T03:49:56ZengWolters Kluwer Medknow PublicationsTungs’ Medical Journal2071-35922949-97202025-01-01191273110.4103/ETMJ.ETMJ-D-24-00027Comparative analysis of brivaracetam and levetiracetam in epilepsy treatmentMing-Yuan HsuShu-Wei HuHueng-Chuen FanEpilepsy affects millions of people worldwide, necessitating effective and safe treatment options. Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that target the synaptic vesicle protein 2A (SV2A). Despite the similarities in their chemical structure, BRV and LEV exhibit distinct pharmacological profiles. This study provides a detailed comparative analysis of BRV and LEV, focusing on their mechanisms of action, preclinical profiles, and pharmacokinetic and pharmacodynamic properties. Clinical trial data highlight the efficacy and safety of both drugs, with BRV showing a higher affinity for SV2A and greater potency in certain seizure models. Additionally, emerging treatment strategies and future directions in epilepsy research are discussed, highlighting the potential for BRV and LEV in advancing epilepsy care.https://doi.org/10.4103/ETMJ.ETMJ-D-24-00027antiepileptic drugsbrivaracetamlevetiracetam |
| spellingShingle | Ming-Yuan Hsu Shu-Wei Hu Hueng-Chuen Fan Comparative analysis of brivaracetam and levetiracetam in epilepsy treatment Tungs’ Medical Journal antiepileptic drugs brivaracetam levetiracetam |
| title | Comparative analysis of brivaracetam and levetiracetam in epilepsy treatment |
| title_full | Comparative analysis of brivaracetam and levetiracetam in epilepsy treatment |
| title_fullStr | Comparative analysis of brivaracetam and levetiracetam in epilepsy treatment |
| title_full_unstemmed | Comparative analysis of brivaracetam and levetiracetam in epilepsy treatment |
| title_short | Comparative analysis of brivaracetam and levetiracetam in epilepsy treatment |
| title_sort | comparative analysis of brivaracetam and levetiracetam in epilepsy treatment |
| topic | antiepileptic drugs brivaracetam levetiracetam |
| url | https://doi.org/10.4103/ETMJ.ETMJ-D-24-00027 |
| work_keys_str_mv | AT mingyuanhsu comparativeanalysisofbrivaracetamandlevetiracetaminepilepsytreatment AT shuweihu comparativeanalysisofbrivaracetamandlevetiracetaminepilepsytreatment AT huengchuenfan comparativeanalysisofbrivaracetamandlevetiracetaminepilepsytreatment |