An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024)
Quinoxaline derivatives have garnered significant attention due to their wide-ranging therapeutic applications. Research from 2020 to 2024 has demonstrated their potent bioactivity across various domains, including anticancer, antimicrobial, antiviral, anti-inflammatory, and antidiabetic activities....
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006854 |
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| author | Aly M. Waseem Ranya Mohammed Elmagzoub Mervat Mohammed Mazhar Abdelgadir Areej Al Bahir N.S. Abd EL-Gawaad Ahmed S. Abdel-Samea Devendra Pratap Rao Konstantinos Kossenas Stefan Bräse Hamada Hashem |
| author_facet | Aly M. Waseem Ranya Mohammed Elmagzoub Mervat Mohammed Mazhar Abdelgadir Areej Al Bahir N.S. Abd EL-Gawaad Ahmed S. Abdel-Samea Devendra Pratap Rao Konstantinos Kossenas Stefan Bräse Hamada Hashem |
| author_sort | Aly M. Waseem |
| collection | DOAJ |
| description | Quinoxaline derivatives have garnered significant attention due to their wide-ranging therapeutic applications. Research from 2020 to 2024 has demonstrated their potent bioactivity across various domains, including anticancer, antimicrobial, antiviral, anti-inflammatory, and antidiabetic activities. Structural modifications guided by structure–activity relationship (SAR) studies have enabled the development of targeted quinoxaline-based compounds with enhanced efficacy. These derivatives interact with critical biological targets such as enzymes, receptors, and signaling pathways, offering promising avenues for treating complex diseases like cancer and infectious diseases. Advanced studies, including molecular docking and ADMET analyses, have further clarified their pharmacological profiles, optimizing their drug-like properties and bioavailability. This review provides a comprehensive overview of the recent advancements in quinoxaline-based therapies, underscoring their potential impact on modern drug discovery and therapeutic applications. |
| format | Article |
| id | doaj-art-d238048469684e9da8fd02abe5acfda4 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-d238048469684e9da8fd02abe5acfda42025-01-29T05:00:49ZengElsevierResults in Chemistry2211-71562025-01-0113101989An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024)Aly M. Waseem0Ranya Mohammed Elmagzoub1Mervat Mohammed Mazhar Abdelgadir2Areej Al Bahir3N.S. Abd EL-Gawaad4Ahmed S. Abdel-Samea5Devendra Pratap Rao6Konstantinos Kossenas7Stefan Bräse8Hamada Hashem9Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Cairo, EgyptDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi ArabiaCollege of Science, Department of Mathematics, Northern Border University, Arar, Saudi ArabiaChemistry Department, Faculty of Science, King Khalid University, Abha 64734, Saudi ArabiaMuhayil Asir, Applied College, King Khalid University, Abha 62529, Saudi ArabiaPharmacology & Toxicology Department, Faculty of Pharmacy, Deraya University, New Minia 61768, EgyptCoordination Chemistry Laboratory, Department of Chemistry, Dayanand Anglo-Vedic (PG) College, Kanpur 208001, Uttar Pradesh, India; Corresponding authors.Department of Basic and Clinical Sciences, University of Nicosia Medical School, P.O. Box 24005, 21 Ilia Papakyriakou, 2414 Engomi, CY-1700 Nicosia, CyprusInstitute for Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany; Corresponding authors.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, EgyptQuinoxaline derivatives have garnered significant attention due to their wide-ranging therapeutic applications. Research from 2020 to 2024 has demonstrated their potent bioactivity across various domains, including anticancer, antimicrobial, antiviral, anti-inflammatory, and antidiabetic activities. Structural modifications guided by structure–activity relationship (SAR) studies have enabled the development of targeted quinoxaline-based compounds with enhanced efficacy. These derivatives interact with critical biological targets such as enzymes, receptors, and signaling pathways, offering promising avenues for treating complex diseases like cancer and infectious diseases. Advanced studies, including molecular docking and ADMET analyses, have further clarified their pharmacological profiles, optimizing their drug-like properties and bioavailability. This review provides a comprehensive overview of the recent advancements in quinoxaline-based therapies, underscoring their potential impact on modern drug discovery and therapeutic applications.http://www.sciencedirect.com/science/article/pii/S2211715624006854QuinoxalineBiological activitiesAnticancerAntimicrobialAntidiabeticAnti-inflammatory |
| spellingShingle | Aly M. Waseem Ranya Mohammed Elmagzoub Mervat Mohammed Mazhar Abdelgadir Areej Al Bahir N.S. Abd EL-Gawaad Ahmed S. Abdel-Samea Devendra Pratap Rao Konstantinos Kossenas Stefan Bräse Hamada Hashem An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) Results in Chemistry Quinoxaline Biological activities Anticancer Antimicrobial Antidiabetic Anti-inflammatory |
| title | An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) |
| title_full | An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) |
| title_fullStr | An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) |
| title_full_unstemmed | An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) |
| title_short | An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) |
| title_sort | insight into the therapeutic impact of quinoxaline derivatives recent advances in biological activities 2020 2024 |
| topic | Quinoxaline Biological activities Anticancer Antimicrobial Antidiabetic Anti-inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006854 |
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